Results 201 to 210 of about 214,122 (263)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Integrating NLP and expert validation: a framework combining subjective and objective approaches for female-oriented automotive personas on social media. [PDF]

Sci Rep
Bao Q, Zhu Q.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Patient Persona of the Self-Management Experience of Home-Based Rehabilitation for Spinal Cord Injury Patients: A Qualitative Study. [PDF]

Patient Prefer Adherence
Wang T, Sun Y, Guo P, Qi N, Zhang Q, Li L.   +5 more
europepmc   +1 more source

Automated chain-of-thought evaluation framework for large language model-generated emergency department documentation: a simulation-based study. [PDF]

Clin Exp Emerg Med
Choi D, Seo J, Cha WC, Kim M, Heo S, Chang H, Kim T.   +6 more
europepmc   +1 more source

Tailored personas for self-management in home-based rehabilitation for participants with lower limb lymphedema: A qualitative study. [PDF]

Int J Nurs Stud Adv
Yin Y, Zhu L, Wang Y, Pu L, Gong J, Han D.   +5 more
europepmc   +1 more source

Digital interventions addressing the unmet needs of older adults with multimorbidity: a mixed-methods persona design approach. [PDF]

Front Public Health
De Luca V, Virgolesi M, Cuomo A, Lemmo D, Perillo M, Canfora F, Aprano S, Mezza F, Vetrani C, Freda MF, Adamo D, Rea T, Mercurio L, Attaianese E, Menditto E, Colao A, Iaccarino G, Illario M.   +17 more
europepmc   +1 more source

Total Knee Arthroplasty for Secondary Osteoarthritis in Patients With Multiple Hereditary Exostoses: A Case Series. [PDF]

Am J Case Rep
Kenai M, Nakano N, Tsubosaka M, Kamenaga T, Kuroda Y, Hayashi S, Kuroda R, Matsumoto T.   +7 more
europepmc   +1 more source

Correction to “Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors”

Molecular Oncology, EarlyView.
wiley   +1 more source