Results 61 to 70 of about 1,953,278 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Rupturas Comportamentales del Consumidor y su Efecto en el Desarrollo Empresarial

PODIUM
El presente artículo plantea supuestos sobre aquellos factores sociales, culturales, personales y psicológicos que influyen en el comportamiento del consumidor y que afectan al desarrollo empresarial de las micros, pequeñas y medianas empresas en el ...
Diego Salazar Duque
doaj   +1 more source

Factors Influencing Undergraduate Students’ Preference of Health Sciences Specialties

Advances in Medical Education and Practice, 2022
Moawia Gameraddin,1 Kamal Al-sultan,1 Suliman Salih,2 Awadia Gareeballah,1 Mohamed Hasaneen,2 Wijdan Alomaim,2 Awatif Omer1 1Department of Diagnostic Radiologic Technology, Faculty of Applied Medical Sciences, Taibah University, Al-Madinah, Saudi Arabia;
Gameraddin M, Al-sultan K, Salih S, Gareeballah A, Hasaneen M, Alomaim W, Omer A   +6 more
doaj  

Personal A-constant in relation to axial length with various intraocular lenses

Indian Journal of Ophthalmology, 2014
Purpose: To study the relationship between the axial length and personal A-constant for the 1-piece Tecnis (Abbott ZCB00), AcrySof MA60AC (Alcon) and the Quatrix aspheric preloaded (CROMA) intraocular lenses (IOL).
Mohamed A Eldaly, Khaled A Mansour
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

La legación española en Lisboa durante el reinado de Fernando VII.

Cuadernos de Historia Contemporánea, 2003
Entre 1808 y 1833 las tensiones y fluctuaciones de la política hispano-portuguesa quedan perfectamente reflejadas en la trayectoria de la legación de Lisboa, en la cual la discontinuidad de los titulares fue la norma.
Mª Victoria López-cordón Cortezo
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Análisis de la respuesta a la pandemia provocada por la COVID-19 en centros residenciales geriátricos de Andalucía

Gerokomos, 2023
Resumen La enfermedad por COVID-19 ha afectado a más de 163 millones de personas alrededor de todo el mundo, azotando con mayor incidencia y gravedad a la población mayor que vivía en residencias para personas mayores. La población mayor ha sido la mayor
María José Calero García, Ana Raquel Ortega Martínez, María Luisa Gascón Grande, Mercedes María Martín Romero   +3 more
doaj