Results 41 to 50 of about 350,905 (262)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
AntropoWebzin, 2016 My study concerns issues dealing with the social rehabilitation of people with spinal cord injuries. I want to show that disability still remains a taboo for many people.
Martina Henrichová
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Personal assistance as a strategic game between state and municipalities in Norway
Scandinavian Journal of Disability Research, 2009 The paper is based on a study of the law-making process of personal assistance in Norway. It discusses some tensions between the state and the municipalities concerning the type and quantity of services with regard to personal assistance.
Jan Andersen
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Disabled people and… Fragments of disability history pointing towards the UN Convention
Fogyatékosság és TársadalomThe Parliament of the Hungarian Republic ratified the Convention on the Rights of Persons with Disabilities, the CRPD in 2007. This modern and pioneering international agreement does not constitute new rights, however, it summarizes the the civil ...
Kogon Mihály
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Personal Assistance for Adults (19‐64) with both Physical and Intellectual Impairments
Campbell Systematic Reviews, 2008 Personal assistance is here defined as paid support of at least 20 hours per week for people with impairments. This Cochrane/Campbell systematic review investigated the effectiveness of personal assistance versus any other form of care for adults with ...
Evan Mayo‐Wilson +2 more
doaj +1 more source