Results 41 to 50 of about 1,304,258 (305)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Nature Through Young Eyes: Exploring Children’s Understanding of Nature in Urban Landscapes in Beijing, China

open access: yesLand
Rapid urbanization over the last few decades has resulted in children growing up in cities increasingly disconnected from the natural world. A better understanding of children’s conceptions of nature in cities is needed to try to address this unfortunate
Jianjiao Liu, Raymond James Green
doaj   +1 more source

The Social Nature of Individual Self-Identity: Akan and Narrative Conceptions of Personhood [PDF]

open access: yes, 2015
Marya Schechtman has given us reasons to think that there are different questions that compose personal identity. On the one hand, there is the question of reidentification, which concerns what makes a person the same person through different time-slices.
Barnes, Corey L.
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A study on the relationship of death anxiety and the completion of advance directives for oncology social workers [PDF]

open access: yes
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Peck, Marlys R., 1964-
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Theory Construction of Teacher's Personal Practice Based on Professional Inquiry: Process, Principle, and Strategy

open access: yesJiaoshi jiaoyu xuebao
In the pursuit of building a country strong in education, the foremost task is to cultivate high-quality teachers. The quintessential traits of such teachers are characterized by possessing a distinctive, comprehensive, practice-oriented, highly refined,
LI Wanwei, XU Xiaodong
doaj   +1 more source

Safeguarding Health at the Workplace: A Study of Work Engagement, Authenticity and Subjective Wellbeing among Religious Workers [PDF]

open access: yes, 2019
: Research in work and organizational psychology has paid little attention to religious workers, something certainly surprising as faith-based organizations play a key role in the welfare state of many countries.
Ariza Montes, José Antonio   +3 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Personal Branding: An Innovative Approach to Life Design Education

open access: yesCERN IdeaSquare Journal of Experimental Innovation
This case study introduces personal branding as an innovation in Career and Life Design. While Life Design offers a roadmap for navigating complex career paths, it requires a deep understanding of one’s identity, values, and aspirations.
Lora Louise Broady
doaj   +1 more source

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