Results 121 to 130 of about 366,516 (307)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

open access: yesAdvanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang   +6 more
wiley   +1 more source

DCC Briefing Paper: Data protection

open access: yes, 2006
The Data Protection Act 1998 ("the DPA") is a piece of UK legislation designed to strike a balance between the interests of the individual in maintaining privacy over their personal details and the possibly competing interests of those with legitimate ...
McGinley, Margaret
core  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

open access: yesAdvanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang   +11 more
wiley   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

open access: yesAdvanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan   +19 more
wiley   +1 more source

CONSTITUTIONALSM - REFORM ON DATA PROTECTION LAW AND HUMAN RIGHTS [PDF]

open access: yes
The purpose of this paper is to address one of the most Fundamental Freedom and Human Rights the protection of privacy, particularly under the provisions of the European Convention on Human Rights as interpreted by the Strasbourg institutions and by ...
Rezana BALLA
core  

The Data Protection Preventive Assessment (DP-PA): Proposal for a New Instrument in Data Protection Law. Practitioners’ Corner

open access: yes
205210Scientific research may be associated with the circumstance that the processing of personal data is not anticipated but cannot be completely ruled out either.However,the EU’s currentlegalframework does not enable unanticipated processing of ...
Selzer, Annika, Boll, Alina
core   +1 more source

Protection of (Personal) Data in Armed Conflicts

open access: yesBaltic Journal of Law & Politics
Despite the increased attention that was given to data protection laws in national jurisdictions – especially after the adoption of the General Data Protection Regulation by the European Union – international law still does not offer a higher standard of
Kelemen Bence Kis
doaj   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

open access: yesAdvanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Home - About - Disclaimer - Privacy