Results 301 to 310 of about 607,001 (343)

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

open access: yesThe FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz   +13 more
wiley   +1 more source

Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and Von Willebrand Disease

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF‐McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology.
Mark W. Skinner   +59 more
wiley   +1 more source

Barriers to the prevention of violence against children identified by healthcare professionals: a scoping review. [PDF]

open access: yesRev Esc Enferm USP
Rodrigues JRGDV   +7 more
europepmc   +1 more source

Health‐Related Quality of Life Among Female Carriers of Haemophilia and Non‐Carriers in a Colombian Population

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Women with haemophilia can present manifestations and experience undiagnosed symptoms, which negatively affect their health‐related quality of life (HRQoL). Objective To evaluate the HRQoL in obligate carriers of haemophilia (OCH) versus women non‐carriers of haemophilia (WNCH) in a Colombian population.
Fabian A. Manzano‐Di Zeo   +9 more
wiley   +1 more source

[Fear of cancer recurrence and primary care utilization in women with breast cancer]. [PDF]

open access: yesAten Primaria
Garduño-Sánchez S   +3 more
europepmc   +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

open access: yesHIV Medicine, EarlyView.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria   +555 more
wiley   +1 more source

Awareness and early implementation of the European AIDS Clinical Society Guidance on statin use in HIV for the primary prevention of cardiovascular disease: A cross‐sectional survey of HIV clinicians in Europe

open access: yesHIV Medicine, EarlyView.
Abstract Objectives Cardiovascular disease (CVD) is a major comorbidity and leading cause of morbidity and mortality in people with HIV (PWH). The REPRIEVE trial demonstrated that statin therapy significantly reduces cardiovascular events in PWH, prompting updated recommendations from major international societies.
Jasmini Alagaratnam   +3 more
wiley   +1 more source

[HEARTS quality: a policy framework to strengthen hypertension and cardiovascular risk management in primary healthcare - insights from HEARTS in the AmericasQualidade da iniciativa HEARTS: marco de políticas para fortalecer o manejo da hipertensão e do risco cardiovascular na atenção primária à saúde. Perspectivas da iniciativa HEARTS nas Américas]. [PDF]

open access: yesRev Panam Salud Publica
Londoño E   +21 more
europepmc   +1 more source

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