Results 51 to 60 of about 17,067,792 (345)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Exposition of process-based learning for first year university students

Collected Essays on Learning and Teaching, 2018
In this expository essay, four faculty members co-reflect on the pedagogy used within one first-year course, Introduction to Community Studies (COMS 1100) at Cape Breton University (CBU).
Bettina Callary, Patrick Maher, Emily Root, Jennifer Ryan   +3 more
doaj   +1 more source

Personal and social development in physical education and sports: A review study

European Physical Education Review, 2019
This review provides an overview of the existing literature on school-aged children’s and youth’s (i.e. 6- to 18-year-olds) personal and social development within the context of physical education and sports.
Katrijn Opstoel, Laurent Chapelle, F. Prins, A. De Meester, L. Haerens, J. van Tartwijk, K. De Martelaer   +6 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An Interdisciplinary Model to Foster Existential Resilience and Transformation

Challenges
Existential threats, including threats to the self, society, and the planet, are present throughout the lifespan and form a core element of the human experience.
Ingela Steij Stålbrand, Ive Brissman, Lovisa Nyman, Erik Sidenvall, Mattias Tranberg, Anika Wallin, Christine Wamsler, Juliet Jacobsen   +7 more
doaj   +1 more source

Evaluating Lifewide Learning Habits of Academicians for Sustainable Development

Discourse and Communication for Sustainable Education, 2016
In today’s higher education institutions in which sustainable development has been highly emphasized, individuals have changed the understanding of graduates of higher education; as such universities have emerged into a reconstruction period.
Soylu Buket Aslandağ, Yelken Tuğba Yanpar, Külekci Mustafa Kemal   +2 more
doaj   +1 more source

Maximising the benefits associated with internship learning for undergraduates

Journal of Learning Development in Higher Education, 2017
This paper focuses on student responses to an internship programme at an American university in London, with the purpose of highlighting potential areas for curricular improvement.
Christine Fanthome
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source