Results 171 to 180 of about 17,112,291 (286)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Exploring Patient Empowerment and Health System Outcomes Associated With MyHealthNB, a Provincial Personal Health Record System: Exploratory Mixed Methods Study. [PDF]

J Med Internet Res
Voorheis P, Dombrowski SU, Bruno F, Steele Gray C.   +3 more
europepmc   +1 more source

Study of the factors influencing the use of MyData platform based on personal health record data sharing system. [PDF]

BMC Med Inform Decis Mak, 2022
Choi W, Chang SH, Yang YS, Jung S, Lee SJ, Chun JW, Kim DJ, Lee W, Choi IY.   +8 more
europepmc   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Hospitals' Adoption of Mobile-Based Personal Health Record Systems and Patients' Characteristics: A Cross-Sectional Study Analyzing National Healthcare Big Data. [PDF]

Inquiry, 2023
Park YT, Park HA, Lee JM, Choi BK.
europepmc   +1 more source

Heterointerface Seeding Accelerates Bi0/Bi3+ Phase Conversion for Ultrafast Aqueous Alkaline Batteries

Advanced Science, EarlyView.
An N‐doped carbon‐confined Bi/Bi2O3 heterostructure enables ultrafast and reversible Bi0/Bi3+ phase conversion through heterointerface seeding. The pre‐established Bi/Bi2O3 interfaces provide nucleation‐active sites for heterophase regrowth, while the N‐C shell promotes electron transport and structural stability, overcoming kinetic limitations in ...
Jingwen Ma, Teng Wang, Jiaye Ye, Tong Yang, Zhongguo Zhao, Yuanyou Peng, Meimei Yu, Chaojiang Fan, Wenhu Li, Hongxia Wang   +9 more
wiley   +1 more source

Effects of a Personal Health Record in Maternity Care: A Stepped-Wedge Trial. [PDF]

Int J Environ Res Public Health, 2021
Groenen CJM, Kremer JAM, IntHout J, Meinders MJ, van Duijnhoven NTL, Vandenbussche FPHA.   +5 more
europepmc   +1 more source

Praseodymium‐Modulated NiFe Layered Double Hydroxide with Enhanced Oxygen Evolution Activity and Extended Durability

Advanced Science, EarlyView.
Pr doping of NiFe‐LDH simultaneously tunes Ni 3d electronics and mesopore architecture. The optimized Ni2Fe0.88Pr0.12‐LDH switches the OER rate‐determining step, delivers 407 mV at 500 mA cm−2, and sustains 2190 h in half‐cell tests. An AEM electrolyzer with this anode operates over 1000 h at industrial current density, offering a durable rare‐earth ...
Yuanming Gao, Xuezhen Wu, Lin Zhang, Haoxiang Zhang, Xueying Feng, Yu Bai, Wei Song, Yong Zheng, Jiong Liu, Jieyu Chen, Dong Yang, Wen Ma, Shengzhong (Frank) Liu   +12 more
wiley   +1 more source

Activation‐Induced Turbostratic Ordering in pDCPD‐Derived Hard Carbon Enables Stable Carbonate‐Based Sodium‐Ion Storage

Advanced Science, EarlyView.
Hard carbon derived from templated poly(dicyclopentadiene) as anode for sodium–ion batteries was engineered through carbonization and second‐step CO2${\rm CO}_2$ activation. High‐temperature carbonization and activation increased local ordering while reducing defects without inducing structural fracture.
David Schuster, Glen J. Smales, Max Schmallegger, Julian M Rosalie, Konstantin Kraushaar, Andreas Lißner, Julia Bohdal, Pia Winter, Bernd Fuchsbichler, Stefan Koller, Sebastijan Kovačič, Christian Slugovc   +11 more
wiley   +1 more source

Frequency of Electronic Personal Health Record Use in US Older Adults: Cross-Sectional Study of a National Survey. [PDF]

JMIR Aging
Agrawal L, DaSouza RO, Mulgund P, Chaudhary P.   +3 more
europepmc   +1 more source