Results 61 to 70 of about 2,616,086 (329)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Procedural Characteristics of Vital Elections of the Studying Men and6Women Depending on Expressiveness of a Personal Maturity

open access: yesРоссийский психологический журнал, 2015
In article results of research of procedural characteristics of vital elections of the studying men and women are stated. Elections of a way of life, career and signiUcant other person act as vital elections of young people.
Юлия Валерьевна Ращупкина
doaj   +1 more source

"Arne Naess between Reason and Emotion." (This paper was the basis for lectures held at the Universities of Prague, Vienna and Belgrade, May 2003) [PDF]

open access: yes, 2003
I try to convince the reader that we all too often consider our decisions more or less unreasonable – and due to emotions overpowering reason. The dualism: reason/emotion may be dangerously misleading.
Naess, Arne
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Before and after : user's knowledge maturity within personal information management. [PDF]

open access: yes, 2013
Personal Information Management (PIM) is an important discipline that evolves with the technology advancements in their operating systems.The understanding of its four main activities in PIM : organizing, retrieving, deleting and archiving are crucial ...
Admodisastro, Novia   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

СПІВВІДНОШЕННЯ ТИПІВ ЕМОЦІЙНОЇ ЗРІЛОСТІ З ДАНИМИ СХИЛЬНОСТІ ДО ОБМАНУ ПРИ ВИКОРИСТАННІ ПОЛІГРАФНОГО МЕТОДУ В ПСИХОЛОГІЇ [PDF]

open access: yes, 2016
У статті представлені результати емпіричного дослідження взаємозв’язку показників емоційної зрілості та даних схильності до обману. Розкрито структуру і особливості емоційної зрілості та узагальнено дані про особливість емоційної зрілості в юнацькому ...
Косьянова, О.Ю.
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

On the Issue of Components of Personal Maturity

open access: yesРоссийский психологический журнал, 2016
The authors analyzed the problems of the formation of personal maturity and made an assumption that the components of personal maturity (ego-identity, active possession of the environment, and self-actualization) would be formed atthe age of seven or ...
Alla А. Gudzovskaya   +1 more
doaj   +1 more source

СТРУКТУРА СТАВЛЕННЯ ДО СЕБЕ СТУДЕНТІВ ЯК КОМПОНЕНТУ СИСТЕМИ ДЕТЕРМІНАНТ СТАНОВЛЕННЯ ОСОБИСТІСНОЇ ЗРІЛОСТІ [PDF]

open access: yes, 2014
У статті представлені варіанти структури ставлення до себе студентів на різних етапах навчання. В основу дослідження покладене уявлення про ставлення до себе як компонент в системі детермінант становлення особистісної зрілості студентів.
Меднікова, Г. І.
core   +1 more source

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