Results 161 to 170 of about 89,900,325 (276)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial. [PDF]

Cancer Prev Res (Phila)
Senter L, Hovick S, Notestine R, Norden L, Benny N, Phillips S, Willoughby A, Pyatt R, Agnese D, Mak JS, DePersia A, Colonna SV, Maxwell WF, Kohlmann W, Spaeth EL, Gordon O, Thull D, Brock GN, Webb A, Smith RM, Toland AE.   +20 more
europepmc   +1 more source

Heterointerface Seeding Accelerates Bi0/Bi3+ Phase Conversion for Ultrafast Aqueous Alkaline Batteries

Advanced Science, EarlyView.
An N‐doped carbon‐confined Bi/Bi2O3 heterostructure enables ultrafast and reversible Bi0/Bi3+ phase conversion through heterointerface seeding. The pre‐established Bi/Bi2O3 interfaces provide nucleation‐active sites for heterophase regrowth, while the N‐C shell promotes electron transport and structural stability, overcoming kinetic limitations in ...
Jingwen Ma, Teng Wang, Jiaye Ye, Tong Yang, Zhongguo Zhao, Yuanyou Peng, Meimei Yu, Chaojiang Fan, Wenhu Li, Hongxia Wang   +9 more
wiley   +1 more source

Understanding Chronic Hip Pain Through the ICF Framework: Implications for Assessment, Diagnosis, and Management. [PDF]

Orthop Surg
You M, Zhou K, Chen X, Zhang X, Li J, Chen G.   +5 more
europepmc   +1 more source

Stretchable h‐BN/TPU Fibers for Passive‐Active Dual‐Mode Thermal Management and Wearable Haptic Interfaces

Advanced Science, EarlyView.
Optimized 30 wt.% h‐BN/TPU fibers create a thermal conductivity of 2.08 W·m−1·K−1 while retaining mechanical compliance (422% elongation at break). Woven fabrics reduce surface temperature by 5.7°C under simulated solar irradiation. Glove integration enables localized fingertip heating at 29.55°C·s−1 with a thermal relaxation time of approximately 20 s.
Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng‐Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu   +12 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Musical Episodic Modulation of Human Functioning: Anticipation Mechanisms, Personal Sense, and Emotional Recall. [PDF]

Integr Psychol Behav Sci
Vieira RD.
europepmc   +1 more source

Praseodymium‐Modulated NiFe Layered Double Hydroxide with Enhanced Oxygen Evolution Activity and Extended Durability

Advanced Science, EarlyView.
Pr doping of NiFe‐LDH simultaneously tunes Ni 3d electronics and mesopore architecture. The optimized Ni2Fe0.88Pr0.12‐LDH switches the OER rate‐determining step, delivers 407 mV at 500 mA cm−2, and sustains 2190 h in half‐cell tests. An AEM electrolyzer with this anode operates over 1000 h at industrial current density, offering a durable rare‐earth ...
Yuanming Gao, Xuezhen Wu, Lin Zhang, Haoxiang Zhang, Xueying Feng, Yu Bai, Wei Song, Yong Zheng, Jiong Liu, Jieyu Chen, Dong Yang, Wen Ma, Shengzhong (Frank) Liu   +12 more
wiley   +1 more source

Basic psychological need satisfaction profiles at work: person-centered links to job crafting and intrinsic motivation. [PDF]

Front Psychol
Coxen L.
europepmc   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source