Results 41 to 50 of about 22,687 (246)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Iterations of work inclusion beyond the standard service

Journal of Comparative Social Work
Employment services are repeatedly criticised for building barriers to service user participation and decent employment due to combinations of conditionality, bureaucratic logics, high caseloads and scarce resources.
Kjetil G. Lundberg, Suzan M. Skjold, Arnhild Melve, Astrid O. Sundsbø   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Intelligent mobile user profile classification for content personalisation [PDF]

, 2009
Mobile device can be used as a medium to send and receive mobile internet content. Although there are several limitations using mobile internet, content personalisation have been viewed as an important area for advancing mobile internet. In this paper we
Wong, K.W., Paireekreng, W.
core  

The more things change, the more they stay the same? The impact of formalising policies on personalisation in paid domestic work - the case of the service voucher in Belgium

Comparative Migration Studies, 2019
Belgium had a long tradition of direct informal employment in paid domestic work, which has undergone formalisation through the introduction of the ‘service voucher system’. This policy triangulates the employment relationship between workers and clients
Anna Safuta, Beatriz Camargo
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Intelligent customer relationship management on the Web [PDF]

, 2005
In recent years, Customer Relationship Management using web personalisation initiatives have gained much attention. The most important strategy of web personalisation is to provide the customers with correct information or services based on the knowledge
Wong, K.W., Fung, C.C., Kok Wong, Xaio, X., Xiong Xiao, Wong, K.P., Chun Fung, Kit Wong   +7 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Tailoring and Personalisation table.

, 2022
Tailoring and Personalisation table.
Christina Van Der Feltz-Cornelis (13993974), Leona Hakkaart-van Roijen (7251794), Jessie Shepherd (13981612), Thirimon Moe-Byrne (109274), Marjo Sinokki (13981606), Päivi Naumanen (13981609), Dorota Merecz-Kot (13981603)   +6 more
core   +1 more source