Results 61 to 70 of about 590,861 (310)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Violent or competitive? Unpacking adolescent cyber-aggressive behavior in text, video, and game context

Frontiers in Psychology
IntroductionCyber-aggressive behavior in adolescents is significantly influenced by violence and competition, yet their distinct roles and interactions with contextual and personality factors remain underexplored.
Yanlei Chen, Lubin Wang, Shaoyang Guo, Qian Gu   +3 more
doaj   +1 more source

Justice Expectations and Applicant Perceptions [PDF]

, 2004
Expectations, which are beliefs about a future state of affairs, constitute a basic psychological mechanism that underlies virtually all human behavior. Although expectations serve as a central component in many theories of organizational behavior, they ...
Bell, Bradford S., Ryan, Anne Marie, Wiechmann, Darin   +2 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Mental Health in a Digital World: How Problematic Cell Phone Use and Personality Predict Fear of Missing Out (FoMO) in Gen Z University Students from Turkiye and the U.S.

Psychiatry and Behavioral Sciences
Objective: The authors sought to examine the association between Fear of Missing Out (FoMO), mental health, personality traits, and social media use among Turkish and U.S. university students, belonging to Generation Z (Gen Z), born between 1997 and 2012,
Peri Yuksel, Sennur Gunay Aksoy, Huiqiao Hou   +2 more
doaj   +1 more source

Improving Emotional Intelligence through Personality Development: The Effect of the Smart Phone Application based Dharma Life Program on Emotional Intelligence

Frontiers in Psychology, 2018
Emotional intelligence is established to predict success in leadership effectiveness in various contexts and has been linked to personality factors.
Latha Poonamallee, Alex M. Harrington, Manisha Nagpal, Alec Musial   +3 more
doaj   +1 more source

Illuminating and applying “The Dark Side”: Insights from elite team leaders [PDF]

, 2014
In contrast to socially desirable behaviors, recent work has suggested that effective elite team leadership also relies on socially undesirable behaviors.
Collins, D., Cruickshank, A.,
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

A emergência do transtorno de personalidade borderline: uma visão comportamental

Interação em Psicologia, 2005
At the end of the past century, borderline personality disorder was established as an important category in psychopathology. A specific historical context made its emergence possible within psychoanalysis.
Ana Carolina Aquino de Sousa, Luc Vandenberghe   +1 more
doaj   +1 more source