Results 51 to 60 of about 40,977 (253)

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Temperament traits and personality disorders. Predictors for personality disorders

Biotechnology & Biotechnological Equipment, 2016
The objective of this study is related to the hypothetical assumption that there are biologically set predispositions as predictors of behavioural and personality disorders.
Hristina Martinova, Iordan Ganev, Vihra Milanova, Latchezar Voynov, Virsavia Vaseva, Krasimir Kostadinov, Tony Donchev   +6 more
doaj   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Psychiatric assessment in image-based sexual abuse case: a case report on imputability in personality disorder with narcissistic traits

Frontiers in Psychiatry
ObjectivesCrimes committed on the Internet and social networks are rising, and the phenomenon is complex. Knowledge of context would be useful for professionals in cases that need psychiatric assessment.
Lorenzo Lodde, Claudia Zandara, Andrea Martella, Mirko Manchia, Mirko Manchia, Pasquale Paribello, Irene Mascia, Martina Pinna   +7 more
doaj   +1 more source

Correction to: Personality Assessment Inventory Cognitive Bias Scale: Validation in a Military Sample [PDF]

, 2023

openalex   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Assessing relationships between conformity and meta-traits in an Asch-like paradigm

Social Influence, 2017
The present study investigated associations between personality and conformity. Early work on this subject employed impactful, experimentally realistic procedures to induce conformity, yet lacked valid personality assessment.
Spee Kosloff, Spencer Irish, Leigh Perreault, Gabrial Anderson, Alexandra Nottbohm   +4 more
doaj   +1 more source

Battery‐Grade Lithium Materials: Virgin Production and Recycling, a Techno‐Economic Comparison

Advanced Energy Materials, EarlyView.
With this study a framework has been created to analyze new innovative lithium compound manufacturing processes for their cost and environmental competitiveness. This analysis includes details on virgin and recycled pathways to produce lithium carbonate or lithium hydroxide monohydrate.
Sabine M. Gallagher, Nighat A. Chowdhury, Qiang Dai, Jeffrey S. Spangenberger   +3 more
wiley   +1 more source

Teoria, avaliação e psicoterapia segundo a proposta de Theodore Millon Theory, assessment and psychotherapy according to Theodore Millon’s proposal

Psico-USF, 2011
Os transtornos da personalidade podem ser compreendidos como construtos teóricos empregados para representar diversos estilos ou padrões em que a personalidade funciona de maneira mal-adaptada em relação ao seu ambiente.
Lucas de Francisco Carvalho
doaj   +1 more source