Results 51 to 60 of about 84,141 (254)

The detrimental impact of maladaptive personality on public mental health: a challenge for psychiatric practice

Frontiers in Psychiatry, 2015
Experts in personality psychology and personality disorders have long emphasised the pervasive and persistent detrimental impact of maladaptive personality traits on mental health and functioning.
Michael Pascal Hengartner
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

The Influence of Attachment Styles and Personality Organization on Emotional Functioning After Childhood Trauma

Frontiers in Psychiatry, 2019
Background: Current literature suggests a tenuous link among childhood trauma, personality organization, adult attachment, and emotional functioning in various psychiatric disorders.
Jürgen Fuchshuber, Jürgen Fuchshuber, Michaela Hiebler-Ragger, Michaela Hiebler-Ragger, Adelheid Kresse, Hans-Peter Kapfhammer, Human Friedrich Unterrainer, Human Friedrich Unterrainer, Human Friedrich Unterrainer   +8 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A bifactor model of personality organization in adolescence: the validity of a brief screening measure assessing severity and core domains of functioning

BMC Psychiatry, 2022
Background Both the latest edition of the DSM-5 as well as the new ICD-11 have established a new focus in the diagnosis of personality disorders: the assessment of personality functioning.
M. Biberdzic, B. F. Grenyer, L. Normandin, K. Ensink, J. F. Clarkin   +4 more
doaj   +1 more source

How many and what mechanisms are needed to explain self‐regulatory functions in personality dynamics: Toward a model based on the Circumplex of Personality Metatraits [PDF]

, 2022
Ewa Skimina, Włodzimierz Strus, Jan Cieciuch, Ewa Topolewska‐Siedzik   +3 more
openalex   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Sex differences in personality dysfunction in help-seeking adolescents

Borderline Personality Disorder and Emotion Dysregulation
Introduction Understanding sex differences is crucial for improving diagnosis and treatment for personality disorders (PDs). This study aimed to investigate sex differences in personality dysfunction as per Criterion A of the DSM-5 Alternative Model of ...
Marialuisa Cavelti, Jana Schenk, Silvano Sele, Corinna Reichl, Julian Koenig, Ines Mürner-Lavanchy, Michael Kaess   +6 more
doaj   +1 more source

Trauma-Related Dissociation Is Linked With Maladaptive Personality Functioning

Frontiers in Psychiatry, 2018
Background: Extensive research has demonstrated the positive associations among the exposure to traumatic experiences, the levels of dissociation, and the severity of psychiatric symptoms in adults.
Antonella Granieri, Fanny Guglielmucci, Antonino Costanzo, Vincenzo Caretti, Adriano Schimmenti   +4 more
doaj   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source