Results 31 to 40 of about 166,361 (267)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Relationship Between Personality Traits and Learning Styles and the AcademicSuccess of Online Students [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2012
Introduction: It is important to consider the factors affecting learning methods. In recent years, virtual education, as a teaching method to fit the needs of today's society, has been considered and the efficacy of this approach has always been ...
Fariba Tabe Bordbar
doaj  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Investigating the Relationship between Personality Type and Field of Study with Smoking Addiction in Medical Students [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Introduction: The increasing prevalence of cigarette smoking among people, especially medical students, finding the reason of this behavior is very important.
Abolfazl Dokhtabdol-Ravasjani, Reyhaneh Shoorizadeh, Fatemeh Refahi, Reza Khorammakan, Seyed Mohammadali Shakertaheri, Aryan Cheraghi   +5 more
doaj  

Analysis of Students' Mathematical Communication Skills in the Perspective of Gender and Personality Type

JRPM (Jurnal Review Pembelajaran Matematika)
This study aims to describe mathematical communication skills in terms of gender and personality type of grade VII students of SMPN 5 Langke Rembong. This research is qualitative research using a descriptive approach.
Bedilius Gunur, Metrisna Restu, Eufrasi Jeramat, Apolonia Hendrice Ramda   +3 more
doaj   +1 more source

Analyzing the Differences in Organizational Commitment and Teamwork Competence by MBTI Personality Type of Aviation Department Students

Hanggong uju uihakoeji, 2023
Purpose: For students who have already decided on their career path by entering the aviation departments, this study aims to analyze organizational commitment and teamwork relationships using the Myers-Briggs Type Indicator (MBTI) personality type as a ...
Seung Joon Jeon, Yun Sick Jung, Ri Hyun Shin   +2 more
doaj   +1 more source

Personality traits in patients with skin diseases

Клинический разбор в общей медицине, 2022
Skin diseases have a significant effect on various aspects of patients' life and can cause psycho-emotional and psychosocial problems, as well as social maladaptation.
Evgeniya V. Dvoriankova, Nikolay A. Shevchenko   +1 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source