Results 51 to 60 of about 76,737 (316)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cross system personalization by factor analysis
, 2022 S.10-18Today, personalization in information systems occurs separately within each system that one interacts with. However, there are several potential improvements w.r.t. such isolated approaches.
Hofmann, T., Fankhauser, P., Mehta, B.
core
Precision or Invasion? Mapping the Personalization Paradox
Journal of Applied Marketing TheoryAI-driven personalization has transformed consumer engagement, yet existing research offers no systematic way to determine when personalization shifts from helpful to intrusive.
Shyamala N Chalakudi, Gnana Bharathy
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Selection of appropriates E-learning personalization strategies from ontological perspectives [PDF]
Interaction Design and Architecture(s), 2010 When there are several personalization strategies of E-learning, authors of courses need to be supported for deciding which strategy will be applied for personalizing each course.
Fathi Essalmi +4 more
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Personalization in the automotive and building sector
, 2022 190199In October 2017, the High-Performance Center »Mass Personalization« was launched in Stuttgart, a research initiative of the local Fraunhofer Institutes and the University of Stuttgart. The pilot phase of 2.5 years focusses on the major requirements
Dangelmaier, Manfred +6 more
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The role of personalization in influencing digital trust and impulse buying in e-commerce
Теоретическая и экспериментальная психологияBackground. In the context of the rapid growth of digital commerce and active implementation of artificial intelligence (AI) in marketing practices, personalization turns to be one of the key strategies for interacting with consumers. In the context of e-
David R. Hayrapetyan +1 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source