Results 251 to 260 of about 4,097,121 (312)

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Clinical harm from failure to deploy personalized medicine for patients with metastatic non-small cell lung cancer. [PDF]

J Manag Care Spec Pharm
Migliaccio-Walle K, Spencer SJ, Veenstra DL, Dumanois RH, White JS, Langer L, Pritchard D, Fox J, Ramsey SD.   +8 more
europepmc   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Interventional Radiology: Towards Personalized Medicine. [PDF]

J Pers Med
Corvino F.
europepmc   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Can generative artificial intelligence enhance evidence-based and personalized medicine? [PDF]

PLoS Med
Thirunavukarasu AJ.
europepmc   +1 more source

Beyond the genome: Public awareness of personalized medicine. [PDF]

Health Promot Perspect
Ghaffarzad A, Harzand-Jadidi S, Milanchian N, Mansouri M, Talebpour A, Mostafaei A, Sharifimoghadam S, Salehi-Pourmehr H, Shahsavarinia K, Hajebrahimi S.   +9 more
europepmc   +1 more source

Artificial intelligence and personalised medicine in liver cancer. [PDF]

J Hepatol
Matuschewski NJ, Baker W, Chapiro J, Calderaro J.   +3 more
europepmc   +1 more source

Multiparametric Abdominal Ultrasound as a Source of Imaging Biomarkers in Predictive and Personalized Medicine: A Narrative Review. [PDF]

Diagnostics (Basel)
Tudor SS, Tupu AE, Ferțu ID, Dumitru CN, Stefan CS.   +4 more
europepmc   +1 more source

Patients' Perspectives on Applications of AI and Personalized Medicine in Life-Threatening Heart Disease: European Cross-Sectional Patient Questionnaire Study. [PDF]

J Med Internet Res
Lindinger GL, Schiermeier NJ, Willems DL, Maris MT, Khattab M, Tan HL, Henzler D, Bak MAR, Nagel E, Lauerer M.   +9 more
europepmc   +1 more source