Results 201 to 210 of about 2,666,075 (354)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Consumer personas for CPAP purchasing in older adults with obstructive sleep apnea: a hospital database study. [PDF]

Future Sci OA
Sawunyavisuth B, Suntrawanichakul S, Heingraj S, Amornpan S, Sawanyawisuth K.   +4 more
europepmc   +1 more source

PROGRAMA DE CAPACITACIÓN ATENCIÓN DE CALIDAD PARA PERSONAS CON DISCAPACIDAD, ENFOCADO EN FUNCIONARIOS DEL ESTADO

, 2021
Francisco Cortés González
openalex   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Automated survey collection with LLM-based conversational agents. [PDF]

JAMIA Open
Kaiyrbekov K, Dobbins NJ, Mooney SD.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Inpatient Participation in Patient Safety Behaviors: Decision-Making Typologies from a Qualitative Study. [PDF]

Risk Manag Healthc Policy
Wang C, Shi H, Du X, Peng Y, Xiao M, Zhao Q, Huang H.   +6 more
europepmc   +1 more source

Personas adultas mayores como dinamizadoras sociales. Un proyecto de intervención sociodeducativa desde la universidad [PDF]

, 2017
Cárdenas Rodríguez, Rocío, Rebolledo Gámez, Teresa   +1 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

'It was something that I let slip by the wayside': a qualitative study of challenges to equitable mpox vaccination in the UK outbreak response. [PDF]

BMC Public Health
Pasin C, Weil B, Hayes R, Siddiqui Q, Whelan I, Nutland W, Maatouk I, Orkin CM, Paparini S.   +8 more
europepmc   +1 more source