Results 51 to 60 of about 404,544 (280)

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Latent profile analysis of moral resilience among clinical nurses and its association with ethical behavior: a multi-hospital cross-sectional study in China

Frontiers in Public Health
ObjectiveTo explore the categories of the moral resilience latent profile of clinical nurses, analyze the influencing factors of different categories, and explore the correlation between them and ethical behavior.MethodsBy convenience sampling, nurses ...
Xiaohan Shi, Ying Zhang, Hongjuan Lang, Rui Wang, Yang Wang, Aiping Sun, Yuan Hui   +6 more
doaj   +1 more source

Peningkatan Citra Dan Kepercayaan Masyarakat Pada Rumah Sakit Milik Pemerintah Melalui Perbaikan Sistem Penyampaian Jasa

Jurnal Manajemen Teori dan Terapan, 2012
The aims of this research is to analyze: 1) the effect of physical support to contact personnel, 2) the effect of service delivery systems that consist of physical support and contact personnel to hospital image, 3) the effect of service delivery systems
Rahab Rahab, Alisa Tri Nawarini
doaj   +1 more source

Allosteric DNAzyme‐Enabled Sensitive and Multiplex Detection of Biomarkers for Rapid Diagnosis of Urinary Tract Infections

Advanced Science, EarlyView.
A catalytic allosteric DNAzyme assay (SMART) is developed by engineering DNAzyme into a unimolecular biosensor, enabling highly sensitive and multiplex detection of small molecules and nucleic acids. SMART enables extraction‐free, one‐pot, one‐step, isothermal, and cost‐effective detection of biological markers, achieving >95% accuracy for rapid ...
Yanzhe Shen, Chenzhi Shi, Xiaowei Ma, Pengfei Hou, Haomin Zhang, Juanxiu Qin, Li Pan, Guilin Li, Lifei Gao, Qian Ma, Donglei Yang, Min Li, Pengfei Wang   +12 more
wiley   +1 more source

The influencing factors of turnover intention among pediatric healthcare workers: a moderated mediation model

Human Resources for Health
Background Turnover intention (TI) is significant for stabilizing the pediatric healthcare workforce and ensuring sufficient pediatric healthcare human resources. This study focuses on the impact and potential mechanisms of person–organization fit (POF),
Qingwen Jia, Wenkang Shi, Hao Yuan
doaj   +1 more source

To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals

Frontiers in Human Neuroscience
Pilot fatigue detection based on physiological signals is practical for aviation safety. Current methods face challenges in balancing the high computational cost of deep learning models with robust accuracy, especially when integrating short-term ...
Kai Chen, Jiming Liu, Jiamei Zhu, Yan Xu, Lin Zhang, Zhenxing Gao   +5 more
doaj   +1 more source

Pathological Complete Response and Long-Term Survival in a Very Elderly Patient after Neoadjuvant Chemotherapy for Locally Advanced, Unresectable Gastric Cancer

Case Reports in Oncological Medicine, 2014
We address the pathological complete response and long-term survival of elderly patients after neoadjuvant chemotherapy in locally advanced, unresectable gastric cancer. An 83-year-old man was hospitalized for upper abdominal pain.
Kunihiko Izuishi, Mitsuyoshi Kobayashi, Takanori Sano, Hirohito Mori, Kazuo Ebara   +4 more
doaj   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Incentive policy for the comprehensive development of young medical talents: an evolutionary game study

Frontiers in Public Health
IntroductionCurrently in China, there is a lack of well-defined and viable incentive mechanisms at the governmental and hospital levels to support the development of young medical talents, thereby hindering their growth Existing studies primarily ...
Si Li, Lijuan He, Yaxin Huang, Dan Wang, Weihua Zhu, Zhisong Chen, Zhisong Chen   +6 more
doaj   +1 more source