Results 271 to 280 of about 4,434,775 (339)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Japanese Adult Day Service Nurses' Bathing Decisions for Persons Requiring Long-Term Care: A Focused Ethnography. [PDF]

Int J Older People Nurs
Miyoshi K, Mori K.
europepmc   +1 more source

Usefulness of the Mini Nutritional Assessment in the screening of sarcopenia in a sample of institutionalized older persons: A cross-sectional study

Esmeralda Garza-Santiago, Ashuin Kammar‐García, Javier Mancilla-Galindo, Martín Lazcano-Hernández, Addí Rhode Navarro-Cruz, Orietta Segura-Badilla, Obdulia Verá-López   +6 more
openalex   +2 more sources

HIV care indicators during the COVID-19 pandemic in relation to pre-pandemic care patterns among people with HIV in North Carolina. [PDF]

AIDS Care
Maierhofer CN, Samoff E, Pence BW, Turner AN, Mobley V, Barnhart J, Miller WC, Powers KA.   +7 more
europepmc   +1 more source

A Critical Appraisal of the Law Protecting Persons with Mental Health Conditions in Zambia

K. Mwaba, Sidney O. C. Mwaba
openalex   +1 more source

Augmented emicizumab-driven coagulation potential in hemophilia A state by <i>in vitro</i> and <i>in vivo</i> supplementation of combined factors IX and X. [PDF]

Res Pract Thromb Haemost
Osuna M, Nakajima Y, Takami E, Nakano H, Nogami K.   +4 more
europepmc   +1 more source

Exposures associated with tuberculosis presentation and healthcare delays in South West England, 2015-2020. [PDF]

PLoS One
Lyness G, Verlander NQ, Beck CR.
europepmc   +1 more source