Results 31 to 40 of about 64,748,975 (303)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Investigation report on the death of Philip S.

, 2003
Cover title.; "Prepared with the assistance of: Anne Broadhurst, Project Manager, State of Connecticut, Office of Protection and Advocacy for Persons with Disabilities"--T.p. verso.; "October 2003"--T.p.
Connecticut. Fatality Review Board for Persons with Disabilities.
core   +1 more source

Effectiveness of representation of the interests of persons with disabilities trough the activities of non-governmental organisations

Socialinis Darbas: Patirtis ir Metodai, 2015
Relevance of the research is determined by the fact that there presentation of the interests of people with disabilities in Lithuania is governed by regulating laws, its legal base issufficiently developed, the process of representation of the people ...
Irmina , Beneševičiūtė
doaj   +1 more source

Autoethnographic Tourism Experience of Wheelchair User in Bali, Indonesia

Indonesian Journal of Disability Studies, 2023
This research presents autoethnography study of a wheelchair-users named Zo during her journey in Bali, Indonesia. Her documentations and field notes are analyzed in four main themes: information accessibility, public facilities accessibility ...
Maudita Zobritania, Muhammad Azhar Widadsyah   +1 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Characteristics and challenges of object search in three-dimensional space via smartphone applications for visually impaired users

Journal of Asian Architecture and Building Engineering
In recent years, the development of applications that utilize image recognition and artificial intelligence to read text and describe the surrounding environment for people with visual impairment has increased.
Momoka Hirai, Megumi Kawasaki, Makoto Kobayashi, Kazuyuki Itoh, Jun Suzurikawa   +4 more
doaj   +1 more source

Neural correlate of human reciprocity in social interactions

Frontiers in Neuroscience, 2013
Reciprocity plays a key role maintaining cooperation in society. However, little is known about the neural process that underpins human reciprocity during social interactions.
Shiro eSakaiya, Yuki eShiraito, Junko eKato, Hiroko eIde, Kensuke eOkada, Kouji eTakano, Kenji eKansaku   +6 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Zbtb20 promotes astrocytogenesis during neocortical development

Nature Communications, 2016
Astrocytes in the brain are derived from neural precursor cells (NPCs). Here, Motoshi Nagao and colleagues show that the transcription repressor Zbtb20 regulates astrocyte specification in the mouse neocortex.
Motoshi Nagao, Toru Ogata, Yasuhiro Sawada, Yukiko Gotoh   +3 more
doaj   +1 more source

GABA Concentration in the Left Ventral Premotor Cortex Associates With Sensory Hyper-Responsiveness in Autism Spectrum Disorders Without Intellectual Disability

Frontiers in Neuroscience, 2020
Individuals with autism spectrum disorder (ASD) often exhibit abnormal processing of sensory inputs from multiple modalities and higher-order cognitive/behavioral response to those inputs.
Yumi Umesawa, Yumi Umesawa, Takeshi Atsumi, Takeshi Atsumi, Mrinmoy Chakrabarty, Mrinmoy Chakrabarty, Reiko Fukatsu, Masakazu Ide   +7 more
doaj   +1 more source