Results 61 to 70 of about 92,465 (306)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Early escitalopram administration as a preemptive treatment strategy against spasticity after contusive spinal cord injury in rats

Scientific Reports, 2021
In the majority of spinal cord injury (SCI) patients, spasticity develops in the subacute phase and chronically persists with muscle hypertonia. Among various pathological conditions underlying spasticity, upregulated expression of 5-HT receptors (5-HTR)
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujita   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Investigation report on the death of JB. [PDF]

, 2003
Cover title.; "Anne Broadhurst, Principal Investigator."; "Information compiled by the State of Connecticut, Office of Protection and Advocacy for Persons with Disabilities, Protection and Advocacy for Individuals with Mental Illness Program"--T.p. verso.
Connecticut. Office of Protection and Advocacy for Persons with Disabilities.
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Supporting Connecticut's citizens with developmental disabilities : final report / [PDF]

, 2002
Cover title.; "P.A. 00-135 Section 19(a) established the Advisory Commission ..."--P. 1.; "July 2002."; Accompanied by summary reports of findings and conclusions by the advisory commission's committees.; "Report on service and support needs of ...
Connecticut. Advisory Commission on Services and Supports for Persons with Developmental Disabilities Who Do Not Have Mental Retardation.
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Accessibility of Persons with Disabilities on the Review of Disability Fiqh

Santri: Journal of Pesantren and Fiqh Sosial, 2020
Accessibility is a form of sympathy and empathy to provide convenience to persons with disabilities by providing friendly public facilities. This study aims to explain how the physical facilities provided by the Pesantren Institute Mathali'ul Falah (IPMAFA) Pati in accommodating people with disabilities in learning and the application of religious fiqh
Puji Lestari, Raodah Raodah
openaire   +3 more sources

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Employment of persons with severe disabilities: procedure manual [PDF]

, 1993
Job hunter's guide to employment with the State of Oregon for persons with severe disabilites -- Oregon Speakers Association -- 1992 members' directory -- Americans with disabilities act."October 1993."This archived document is maintained by the State ...

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