Results 121 to 130 of about 7,625,136 (322)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Reduced description of nonequilibrium processes and correlation functions. Divergences and non-analyticity

Condensed Matter Physics, 2006
A complete theory for investigation of time correlation functions is developed on the basis of the Bogolyubov reduced description method proceeding from his functional hypothesis.
A.I.Sokolovsky
doaj   +1 more source

Electrodynamic theory of ferromagnetic resonance and its applications in precise measurements of ferromagnetic linewidth, permeability tensor and saturation magnetization

AIP Advances, 2020
This review paper describes the state of the art in measurements of ferromagnetic linewidth, permeability tensor and saturation magnetization employing electrodynamic theory of ferromagnetic resonance.
Jerzy Krupka, Adam Pacewicz, Bartłomiej Salski, Paweł Kopyt   +3 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Asymptotic safety within on-shell perturbation theory

Journal of High Energy Physics
We investigate the renormalisation of Einstein gravity using a novel subtraction scheme in dimensional regularisation. The one-loop beta function for Newton’s constant receives contributions from poles in even dimensions and can be mapped to the beta ...
Kevin Falls, Renata Ferrero
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

String perturbation theory of Klebanov-Strassler throat

Journal of High Energy Physics
In this work, we develop a tool to study string perturbation theory of the Klebanov-Strassler solution in the large radius approximation based on open-closed superstring field theory.
Manki Kim
doaj   +1 more source

Perturbation Theory and Relative Space

, 1994
The validity of non-perturbative methods is questioned.
Veltman, M.
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source