Results 41 to 50 of about 1,792,397 (160)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Aprendizagem e inovação na indústria farmacêutica indiana: o papel da

RECIIS, 2008
Durante as décadas de 1970 e 1980, a indústria farmacêutica indiana (IFI) atingiu patamares impressionantes de maturidade tecnólogica. Na conjuntura atual, porém, a indústria se encontra tentando enfrentar os desafios da globalização e reformas. Ela está
Amit Shovon Ray
doaj   +1 more source

Copaiba Oil Resin Exerts an Additive Effect to Babassu Oil on Behavioral Changes in Human Endometriotic Cell Cultures

Pharmaceuticals, 2022
Background: Current drugs for the treatment of endometriosis are not able to completely cure the condition, and significant side effects hinder the continuation of treatment. Therefore, it is necessary to search for new drug candidates.
Julianna Henriques da Silva, Leticia Coli Louvisse de Abreu, Renato Ferrari, Celia Yelimar Palmero Quintana, Eliane Gouvêa de Oliveira Barros, Natália de Moraes Cordeiro, Bruno Pontes, Valeria Pereira de Sousa, Lucio Mendes Cabral, Patricia Dias Fernandes, Luiz Eurico Nasciutti   +10 more
doaj   +1 more source

Synergistic Phytochemicals From Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Schum. and Lantana camara Linn. in Chitosan Biofilms: Antioxidant and Anti‐Inflammatory Activities With Wound‐Healing Potential

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Biodegradable chitosan films loaded with a 1:1 combination of Mitracarpus frigidus and Lantana camara extracts demonstrated potent antioxidant, anti‐inflammatory, and wound‐healing properties, while exhibiting low cytotoxicity and favorable physicochemical characteristics.
Natasha Silva Mayrink, Julia Bertolini Fajardo, Mariane Rocha Cordeiro Comitre, Lucas de Araújo Carvalho, Mariana Iasbeck Dalcol, Priscila de Lima Paula, Lara Melo Campos, Maria Clara Machado Resende Guedes, Luiz Fernando Cappa de Oliveira, Elaine Soares Coimbra, Gilson Costa Macedo, Ângelo Márcio Leite Denadai, Ari Sérgio de Oliveira Lemos, Rodrigo Luiz Fabri   +13 more
wiley   +1 more source

Alocação de recursos públicos para saúde em Macaé entre 2014 e 2017: Reflexões e Desafios

Jornal de Assistência Farmacêutica e Farmacoeconomia
Objetivos: Demonstrar a alocação de recursos repassados pelo Fundo Nacional de Saúde para cada Bloco de Financiamento da Saúde do município de Macaé entre 2014 e 2017.
Natalia Silos Alves, Danielle Maria de Souza Serio dos Santos, Jéssica Fernandes de Souza, Rebeca Reis Silva, Isabella Piassi Dias Godói   +4 more
doaj   +1 more source

Micro‐QuEChERS Extraction for Broad‐Spectrum LC‐QQQ‐MS Quantification of Nitazene Analogs in Plasma: A Validated Method With Casework Application

Drug Testing and Analysis, Volume 18, Issue 10, Page 1296-1310, October 2026.
Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza, Náthaly C. B. F. Santos, Rafael Lanaro, Sara E. Walton, Alex J. Krotulski, Barry K. Logan, Mauricio Yonamine, Jose Luiz Costa   +7 more
wiley   +1 more source

Triplet Acetone Generation by Pseudoperoxidase Activity of Myoglobin: Structural Damage and Quenching

Luminescence, Volume 41, Issue 9, September 2026.
Ferrimyoglobin pseudoperoxidase activity was demonstrated during isobutyraldehyde oxidation, yielding electronically excited triplet acetone and inducing structural damage. Sorbates and 9,10‐dibromoanthracene‐2‐sulfonate exhibited protective effects.
Thiago M. V. Gomes, Cassius V. Stevani, Kostas Pantopoulos, Luiz D. Ramos, Etelvino J. H. Bechara   +4 more
wiley   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source

A publicidade de alimentos e o direito à saúde

Revista de Direito Sanitário, 2007
Este trabalho analisa a monitoração e fiscalização da propaganda de produtos sujeitos à vigilância sanitária, um processo influenciado por mudanças sociais e econômicas, pela evolução da ciência e pelo ordenamento jurídico.
Maria José Delgado Fagundes, Rodrigo Fagundes Souza   +1 more
doaj  

A INDÚSTRIA FARMACÊUTICA E A IMPORTÂNCIA ESTRATÉGICA DOS PROPAGANDISTAS DE MEDICAMENTOS: ESTUDO COM COLABORADORES EM NATAL/RN

Holos, 2014
A indústria Farmacêutica é um mercado competitivo, complexo e de investimentos vultosos em pesquisa, desenvolvimento e produção de produtos farmacêuticos.
Helio Roberto Hekis, Kleber Cavalcante Sousa, Marcio Furukava, Ricardo Alexsandro de Medeiros Valentim, Idelmárcia Dantas de Oliveira, Robinson Luis de Souza Alves   +5 more
doaj   +1 more source