Results 161 to 170 of about 533,514 (236)

Technological arrangements for regulating access to healthcare: experience in the state of São Paulo. [PDF]

Rev Saude Publica
Freire MP, Chioro A, Tofani LFN, Bigal AL, Louvison MCP.   +4 more
europepmc   +1 more source

GLP‐1 Receptor Agonists in Brazil: Landscape of Consumption, Safety and Regulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4185-4193, May 2026.
ABSTRACT Background The escalating use of Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is reshaping pharmaceutical consumption patterns and posing unprecedented challenges to healthcare systems worldwide. This study analyzes the landscape of GLP‐1 RA consumption, safety monitoring and regulatory oversight in Brazil.
Renato Lopes Hurtado, Angélica Amorim Amato, Hugo de Luca Corrêa, Dâmaris Silveira   +3 more
wiley   +1 more source

Lifelong Exercise as a Modulator of CD4+ T Cell Immunometabolism

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Hypothetical framework illustrating how physical exercise initiated early in life acts as a critical immunomodulatory factor by promoting optimal immune function from childhood and establishing a better “immunometabolic functional peak”. This early advantage may confer sustained benefits to CD4+ T cell metabolism and immune competence across aging ...
Bruna Spolador de Alencar Silva, Amanda Veiga Sardeli, Ricardo R. Agostinete, Helena Batatinha, Alessandra Peres, José César Rosa‐Neto, José Teixeira, Manuel J. Coelho‐e‐Silva, Paulo J. Oliveira, Fábio Santos Lira   +9 more
wiley   +1 more source

Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss

International Endodontic Journal, Volume 59, Issue 5, Page 873-889, May 2026.
ABSTRACT Aim To investigate whether moderate systemic caffeine intake modulates the progression of apical periodontitis (AP) and associated alveolar bone loss, combining in vivo rat experiments with in silico molecular docking to explore potential mechanisms. Methodology Male Wistar rats were randomly assigned to four groups (n = 8 per group): control,
Matheus Ferreira Lima Rodrigues, Deborah Ribeiro Frazão, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos, Felipe Oliveira Nunes, João Daniel Mendonça de Moura, Thamires Campos Gomes, Jorddy Neves Cruz, Cristiane do Socorro Ferraz Maia, Rodrigo A. Cunha, Fabrício Mezzomo Collares, Rogerio de Castilho Jacinto, Rafael Rodrigues Lima   +12 more
wiley   +1 more source

N‐Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis

International Endodontic Journal, Volume 59, Issue 5, Page 890-902, May 2026.
ABSTRACT Aim This study aimed to evaluate the effects of N‐acetylcysteine (NAC) supplementation in apical periodontitis (AP) induced in rats. Methodology Eighteen male Wistar rats were randomly assigned to three groups: control, AP, and AP plus NAC.
Ian Wesley Rocha dos Santos, Deiweson Souza‐Monteiro, Deborah Ribeiro Frazão, Zuleni Alexandre Lisboa da Silva, João Daniel Mendonça de Moura, Jorddy Neves Cruz, Fabrício Mezzomo Collares, Renata Duarte de Souza‐Rodrigues, Luciano Tavares Ângelo Cintra, Rafael Rodrigues Lima   +9 more
wiley   +1 more source

Effects of Ozonized Oil on At‐Home Tooth Bleaching: A Double‐Blind Randomized Clinical Trial

Journal of Esthetic and Restorative Dentistry, Volume 38, Issue 5, Page 921-929, May 2026.
ABSTRACT Objective This double‐blind, randomized clinical trial evaluated the effect of ozonized sunflower oil on tooth sensitivity, color change, and patient perception during at‐home bleaching with 10% hydrogen peroxide. Clinical Considerations Forty participants were randomly assigned to receive ozonized or nonozonized sunflower oil, applied in ...
Murilo Guimarães Campolina, Lia Dietrich, Julia Marques Martins, Larissa Victoria Miranda Ubagai, Guilherme José Pimentel Lopes Oliveira, Ceci Nunes Carvalho, Hugo Lemes Carlo, Carlos José Soares, Gisele Rodrigues Silva   +8 more
wiley   +1 more source

Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins, Guillaume Nugue, Andrey Aguiar, Leticia R. Q. Souza, Paulo V. Abrantes, Julia Rodrigues Trajano, Mariana Stelling, Magno Junqueira, Stevens Rehen, Marília Zaluar P. Guimarães   +9 more
wiley   +1 more source

Brazil is already experiencing the brutal impacts of climate change. [PDF]

Rev Saude Publica
Lorenz C, Cavendish TA, Azevedo TS, Bell M, Nardocci A, Andrade MF, Nogueira T.   +6 more
europepmc   +1 more source

Vaccination Coverage and Factors Associated With Incomplete Vaccination Schedules in Children Under 5 in a Peripheral Area of the Federal District of Brazil

Public Health Nursing, Volume 43, Issue 3, Page 543-553, May/June 2026.
ABSTRACT Objective To estimate vaccination coverage (VC) and analyze the factors associated with the incomplete vaccination schedule (IVS) in children under 5 years of age in two Basic Health Units in the Federal District of Brazil. Design A cross‐sectional study.
Ivea Rayane Mendes Nicacio Viana, Henry Maia Peixoto   +1 more
wiley   +1 more source

Coronavirus Detection in Bats Captured on the Deforestation Arc of Mato Grosso, Brazil

Zoonoses and Public Health, Volume 73, Issue 3, Page 281-287, May 2026.
ABSTRACT Coronaviruses (CoV) are RNA viruses associated with enteric and respiratory diseases and known for their emergence potential in humans and other mammals. CoVs originate from zoonotic transmission, in which bats are natural reservoirs. Previous studies suggest that CoV diversity is positively correlated with bat diversity, whereas anthropogenic
Matheus Augusto Calvano Cosentino, Victor Wanderkoke, Francimeire Fernandes Ferreira, Sergio Gomes Silva, Mirela D'arc, André Felipe Andrade dos Santos   +5 more
wiley   +1 more source