Results 291 to 300 of about 652,932 (410)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

open access: yesAngewandte Chemie International Edition, EarlyView.
A biosynthesis route for the polymer precursor tulipalin A starting from isoprenyl acetate is proposed. The alkane monooxygenase AlkB catalyzes the chemoselective terminal hydroxylation of isoprenyl acetate. Rational enzyme engineering further increased the activity of the membrane enzyme.
Andrea Nigl   +11 more
wiley   +1 more source

Building a Bridge Between Ambient MS and LC‐MS by Non‐Exhaustive Microdesorption

open access: yesAngewandte Chemie International Edition, Accepted Article.
Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects and limited selectivity. The absence of a separation step can also lead to false positives due to the isomers or isobars.
Wei Zhou, Janusz Pawliszyn
wiley   +1 more source

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