Results 21 to 30 of about 3,796,309 (254)
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018 The views of the Russian conservatives of the first quarter of the 19th century on the life and reforms of Peter I are not fully understood. The views of publicist S.N. Glinka about Peter the Great are considered.
R. R. Dzhabbarov
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npj Breast Cancer, 2023 Novel therapeutic strategies that can effectively combine with immunotherapies are needed in the treatment of triple-negative breast cancer (TNBC). We demonstrate that combined PARP and WEE1 inhibition are synergistic in controlling tumour growth in ...
Zhi Ling Teo +15 more
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OksidentThe first of the problems that arose among the early Christian believers in Jesus centered around the relationship of the Mosaic Law to gentile believers.
Yunus Kaymaz
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Stereotactic radiotherapy for oligoprogressive ER-positive breast cancer (AVATAR)
BMC Cancer, 2021 Background The enhanced knowledge of cancer biology has led to considerable advancement in systemic therapy for advanced breast cancer. Recently, studies showed that cyclin-dependent kinase (CDK) 4/6 inhibitor, when added to endocrine therapy, had ...
Reem Alomran +9 more
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Review of the Book “Peter I in Media Memory” by Denis S. Artamonov & Sophia V. Tikhonova
Галактика медиа: журнал медиа исследований, 2023 The subject of the review is a monographic study by S. V. Tikhonova and D. S. Artamonov “Peter I in Media Memory”. The monograph consists of three chapters and fourteen paragraphs.
Ivan V. Suslov
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Primary and metastatic breast tumors cross-talk to influence immunotherapy responses
OncoImmunology, 2020 The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immune microenvironment in distal tissues through the circulation, and therefore influence the efficacy of immunotherapies to ...
Amanda J Oliver +8 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
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