Results 131 to 140 of about 20,698 (215)

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Automatic construction of Petri net models for computational simulations of molecular interaction network. [PDF]

NPJ Syst Biol Appl
Lin X, Chang X, Zhang Y, Gao Z, Chi X.
europepmc   +1 more source

PEPN-GRN: A Petri net-based approach for the inference of gene regulatory networks from noisy gene expression data. [PDF]

PLoS One, 2021
Vatsa D, Agarwal S.
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Formal modeling of a causal consistent distributed system and verification of its history <i>via</i> model checking using colored Petri net. [PDF]

PeerJ Comput Sci
Alsaegg KAM, Pashazadeh S, Zolfy Lighvan M.   +2 more
europepmc   +1 more source

Hybrid Cyber Petri net Modelling, Simulation and Analysis of Master-Slave Charging for Wireless Rechargeable Sensor Networks. [PDF]

Sensors (Basel), 2021
Qin H, Zhao B, Xu L, Bai X.
europepmc   +1 more source

Tailoring Multifunctional Carbon Dots via Precursor Stoichiometry: Switching Between Solid‐State Fluorescence and Broadband Absorption Through Aggregation Control

Advanced Science, EarlyView.
Precursor stoichiometry programs the surface chemistry of carbon dots, directing their self‐assembly into distinct aggregation modes. Aldehyde‐enriched surfaces form ordered, hydrogen‐bonded assemblies that enable bright red solid‐state fluorescence, whereas amine‐rich surfaces promote compact π–π stacked aggregates with broadband visible‐light ...
Gaixia Yang, Hao Sun, Defa Hou, Fulin Yang, Yuan Zou, Bei Zhou, Lanxiang Liu, Xu Lin, Guanben Du   +8 more
wiley   +1 more source

Petri-Net-Based Charging Scheduling Optimization in Rechargeable Sensor Networks. [PDF]

Sensors (Basel)
Qin H, Ding W, Xu L, Ruan C.
europepmc   +1 more source

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source

Editorial Note: Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis. [PDF]

PLoS Comput Biol
PLOS Computational Biology Editors.
europepmc   +1 more source