Results 311 to 320 of about 3,623,879 (377)

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan, Hongyi Chen, Haolin Song, Chufeng Li, Yu Wang, Zhenhao Zhao, Qin Guo, Xuwen Li, Mingxuan Liu, Tao Sun, Chen Jiang   +10 more
wiley   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

Advanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan, Hai Tang, Lanlan Wang, Qingfeng Bai, Yi Chen, Runfeng Cao, Weikang Lin, Lei Wang, Yulong Hu, Guofang Zhao, Minglei Yang, Weiyan Sun, Kun Zhang, Dawei Li, Chang Chen   +14 more
wiley   +1 more source

Multifunctional and Flexible Phase Change Composites for Dual‐Mode Thermal Management of Lithium‐Ion Batteries

Advanced Science, EarlyView.
This study develops flexible, leakage‐proof phase change composites with dual‐mode thermal management for lithium‐ion batteries. The composites offer Joule heating, passive cooling, and temperature sensing. Simulations validate their performance and provide insights into material optimisation.
Lichang Lu, Haosong He, Hongxu Guo, Ignacio Martin‐Fabiani, Emiliano Bilotti, Han Zhang, Ashley Fly, Yi Liu   +7 more
wiley   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation.

Adv Biomed Res, 2016
Nickaeen N, Moein S, Heidary Z, Ghaisari J.   +3 more
europepmc   +1 more source

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Possibilistic Petri nets

IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics), 1999
This paper presents the possibilistic Petri net model which combines possibility logic with Petri nets with objects. The main feature of this model is to allow one to reason about the aspects of uncertainty and change in dynamic discrete event systems.
Cardoso, Janette, Valette, Robert, Dubois, Didier   +2 more
openaire   +5 more sources

Using Petri nets as a model for Petri nets

Proceedings of the Third Workshop on Future Trends of Distributed Computing Systems, 2003
This paper deals with the study of behavioral equivalences between labeled (place/transition) Petri nets preserving the causal relationship among transition firings. This is achieved by defining a very slight modification in the conventional Petri net formalism, leading to associating an additional information to each token of the net.
Jean-Pierre Courtiat, R.J. Coelho da Costa   +1 more
openaire   +2 more sources

Petri Nets with Time

2013
In previous chapters, Place/Transition nets have been used to model Discrete Event Systems with the aim of analyzing logical properties. However, such a model is not suitable for performance analysis because it does not keep into account the duration of the activities occurring in a system.
Bérard B, Cabasino MP, Di Febbraro A, GIUA, ALESSANDRO, SEATZU, CARLA   +4 more
openaire   +3 more sources

The dimensions of Petri nets: The Petri net cube

Bulletin of The European Association for Theoretical Computer Science, 1998
Summary: There exist many different Petri net formalisms. In this paper, we present the Petri net cube which helps to structure and classify the variety of Petri net formalisms. We show, that three basic aspects are sufficient for describing most classical Petri net formalisms.
Ekkart Kindler, Michael Weber
openaire   +3 more sources