Results 131 to 140 of about 414,789 (300)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Evaluation of rock and fluid intermolecular interaction between asphaltene and sand minerals using electrochemical, analytical spectroscopy and microscopy techniques

Scientific Reports
Long-time contact of heavy crude oil with rock leads to an adsorption phenomenon, which causes the rock surface to become oil-wet and appears as a barrier to the fluid flow in the porous media.
Jaber Taheri-Shakib, Ali Esfandiarian, Mahyar Rajabi-Kochi, Ezzatallah Kazemzadeh, Mohammad Afkhami Karaei   +4 more
doaj   +1 more source

Oil price controls: a counterproductive effort [PDF]

Petroleum industry and ...
Hans H. Helbling, James E. Turley
core  

On the Origins of Toughness in Corymbia calophylla (Marri Tree) Nuts

Advanced Science, EarlyView.
We uncover the natural toughening mechanisms of the marri nut, including fiber pullout, crack deflection, and a viscoelastic matrix, which enable exceptional energy absorption and ductility comparable to Teflon, with an elastic modulus similar to acrylic.
Wegood M. Awad, Ahmed S. Dalaq, Marieh B. Al‐Handawi, Rezo Getsadze, Oraib Al‐Ketan, James Weston, Mohammed Daqaq, Panče Naumov   +7 more
wiley   +1 more source

Slow job growth in Houston in 2002 [PDF]

Employment - Texas ; Petroleum industry and ...
Robert W. Gilmer
core  

Application of NASTRAN to a fluid solids unit in the petroleum industry [PDF]

, 1975
The application of NASTRAN to the design of a fluid solids unit plenum/cyclone/dipleg assembly is described. The major loads considered are thermal, pressure, and gravity.
Nelson, N. W.
core   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Oil imports and the fall of the dollar [PDF]

Petroleum industry and trade ; Money ...
Douglas R. Mudd, Geoffrey E. Wood
core  

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

Thermodynamic analysis and intelligent modeling of statin drugs solubility in supercritical carbon dioxide

Scientific Reports
Evaluating the solubility of various drugs in supercritical CO2 is a fundamental step in developing a supercritical process for formulating new pharmaceuticals.
Mitra Amani, Abbas Shahrabadi, Nedasadat Saadati Ardestani   +2 more
doaj   +1 more source