Results 91 to 100 of about 167 (166)
Advanced Science, EarlyView.The study develops a H•/H– transfer strategy enabling efficient hydrocyclization/defluorination of CF3‐acrylamides to synthesize Seletracetam derivatives with gem‐difluoroalkenes. Mechanistic studies reveal distinct pathways: the NiII‐H/PhSiH3 system operates through a hydrogen atom transfer process, while the 1,4‐Michael addition of H– appears to be ...
Yanjun Wan, Ronghui Shao, Jack R. Norton
wiley +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Advanced Science, EarlyView.Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi +12 more
wiley +1 more source
Advanced Science, EarlyView.A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.The synthesis of a range of squaraine dyes is reported with maximum absorption in solution above 1100 nm. Near‐infrared sensitive organic photomultiplication photodetectors are developed. Photomultiplication occurs via squaraine hole trap‐induced injection of electrons from the external circuit.
Joshua Csucker +9 more
wiley +1 more source
Advanced Science, EarlyView.A filterable paper‐based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one‐to‐one recognition and simultaneous quantification of multiple antibiotics. Three representative MOFs are strategically designed to exhibit exceptional affinity and specificity for the target antibiotic.
Tongtong Ma +7 more
wiley +1 more source
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Advanced Science, EarlyView.Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang +13 more
wiley +1 more source
Mixed‐Dimensional Floating Gate Phototransistors for Mixed‐Modal In‐Sensor Reservoir Computing
Advanced Science, EarlyView.Designing bio‐inspired multisensory neuromorphic devices holds significant importance for low‐power and high‐efficiency computing. Here, the authors introduce a floating‐gate phototransistor based on the mixed‐dimensional heterostructure of 0D‐CsPbBr3 QDs and 2D‐MoS2 few layers.
Weilun Ouyang +9 more
wiley +1 more source
Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides
Advanced Science, EarlyView.A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu +5 more
wiley +1 more source
Advanced Science, EarlyView.A schematic illustration of the cyanobacteria‐based biohybrid platform for photodynamic cancer therapy enhanced PDT. The platform continuously outputs O2 (to alleviate tumor hypoxia) and 1O2 (for tumor treatment), achieving improved photodynamic immunotherapy. Abstract The interdisciplinary development of synthetic biology and material sciences propels
Zhengwei Xu +14 more
wiley +1 more source