Results 61 to 70 of about 167 (166)

Direct Access to α,β‐Unsaturated γ‐Lactams via Palladium‐Catalysed Carbonylation of Propargylic Ureas.

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Additive carbonylations typically necessitate strong nucleophiles, such as alcohols or amines. In this study, we carbonylated a poorly nucleophilic urea, under oxidant‐free conditions. Our straightforward carbonylative strategy enables access to versatile α,β‐unsaturated γ‐lactams featuring an aminocarbonyl fragment, utilizing readily ...
Debora Schiroli, Aleksandr Voronov, Francesco Pancrazzi, Nunzio Iraci, Salvatore Vincenzo Giofrè, Beatrice Macchi, Valeria Stefanizzi, Raffaella Mancuso, Bartolo Gabriele, Paolo Pio Mazzeo, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source

Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract In this work, we extend the one‐pot protocol to synthesize 1,2‐diazepines from commercially available and cheap starting materials. Capitalizing on isocyanate derivatives as activating agents, the photochemical skeletal enlargement occurs, while preserving key functional groups embedded in more than 30 substrates.
Clément Ghiazza, Aurélie Damond, Jérôme Marrot, Xavier Moreau   +3 more
wiley   +1 more source

Mg(SPh)2 as a Catalyst for Efficient Photocatalytic Alkylation Reactions of Active Methylene Compounds with Nonactivated Alkenes

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Mg(SPh)2 has been found to be a highly active catalyst in photocatalytic alkylation reactions of active methylene compounds with nonactivated alkenes. The desired reactions proceeded smoothly to afford the corresponding alkylated products in high yields with low catalyst loadings (0.2–0.3 mol%). This protocol is applicable to a continuous‐flow
Yasuhiro Yamashita, Tomoya Hisada, Yuki Sato, Shū Kobayashi   +3 more
wiley   +1 more source

Tunable Preparation of β‐Substituted Alkenoate Esters via Radical Alkenylation of C(sp3)–H Bonds with Allenoates

Advanced Synthesis &Catalysis, EarlyView.
Abstract A photocatalytic strategy for the radical alkenylation of aliphatic C(sp3)–H bonds with 2,3‐allenoate esters is described. The protocol takes place upon irradiation of the reaction mixture in the presence of the decatungstate anion, which triggers C−H cleavage in the chosen aliphatic substrates.
Alexandra Jorea, Roberto Chessa, Davide Ravelli   +2 more
wiley   +1 more source

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

Synthesis of spirolactones from carbonyls via carboborylation of N‐sulfonylhydrazones with alkoxycarbonylalkylboronic acids

Advanced Synthesis &Catalysis, Accepted Article.
A straightforward synthesis of spirolactones from carbonyls via N‐tosylhydrazones is described. The process consist in the reaction between the N‐tosylhydrazone and ethoxycarbonylethylboronic acid or ethoxycarbonylpropylboronic acid, leading to spiro γ‐butyrolactones or δ‐valerolactones respectively. The transformation takes place by carboborylation of
Lucía López, Sara Filgueira, María-Paz Cabal, Alfonso Carlos Valdés-Gómez   +3 more
wiley   +1 more source

Pot‐Economical Synthesis of Fluorinated Pyrrolizinone Derivatives

Advanced Synthesis &Catalysis, EarlyView.
Abstract A new family of fluorinated dihydropyrrolizinones has been synthesized starting from fluorinated enamino amides and aliphatic conjugated ketones. The reaction comprises a cross metathesis reaction followed by a tandem cycloaromatization/ enamine hydrolysis/ intramolecular Friedel‐Crafts alkylation sequence.
Lidia Prieto, Marcos Escolano, Daniel Gaviña, Luis Paredes‐Soler, Santiago Díaz‐Oltra, María Sánchez‐Roselló, Carlos del Pozo   +6 more
wiley   +1 more source

Synthesis of Polysubstituted Naphthalenes via Metal‐Free Borylative Cyclization of o‐Alkynylstyrenes

Advanced Synthesis &Catalysis, EarlyView.
Abstract A selective, metal‐free method for the synthesis of boron‐functionalized polysubstituted naphthalenes via BCl3‐mediated cyclization of α‐substituted o‐alkynylstyrenes is described. The reaction exhibits broad substrate scope, tolerating various groups such as ethers, sulfides and halogens, and delivers high yields under mild conditions, even ...
Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +2 more
wiley   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, EarlyView.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

Development of Hydrofluoroolefin (HFO)‐Based Direct O‐Fluoroalkenylation of Phenols Targeting Tyrosine Conjugation

Advanced Synthesis &Catalysis, EarlyView.
Abstract Methodology for direct fluoroalkenylation of phenolic OH function was developed using a fluorinated electrophilic reagent derived from HFO1234ze gas. Besides various functionalized phenols, tyrosine and tyrosine‐based peptides were successfully conjugated under the optimized reaction conditions.
Rihárd Sisa, Ferenc Béke, Zoltán Novák   +2 more
wiley   +1 more source