Results 71 to 80 of about 488,297 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Histopathological Study of Canine Skin Hemangiomas and Hemangiosarcomas in Uruguay

open access: yesPets
We performed an histological study on all cases of canine skin hemangiomas and hemangiosarcomas that were examined between 2018 and 2020. Of the 446 dogs with skin tumors examined, 25 were diagnosed with hemangiomas and 24 were diagnosed with ...
Belén Varela   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Survey About Management of Diabetes Mellitus in Dogs and Cats Among Veterinarians in the United Kingdom and Continental Europe

open access: yesPets
This study aimed to obtain information on veterinarians’ experience regarding the management of diabetes mellitus (DM) in the United Kingdom and Europe.
Tereza Jaresova   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genomic and Plasmid Distribution of Clinically Relevant Antibiotic Resistance Genes in Pets and Free-Roaming Dogs in an Urban Area of Central Mexico

open access: yesPets
Dogs, especially as pets but also an increasing number of stray dogs, share environments with humans, facilitating the transfer of antibiotic resistance genes (ARGs) between genetic compartments, with zoonotic and public health implications that must be ...
María Daniela Frade-Pérez   +7 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Information Could Reduce Consumer Demand for Exotic Pets

open access: yes, 2017
The global wildlife trade is a growing threat to biodiversity, species conservation and animal welfare. A major driver is consumer demand for exotic pets, and there have been calls for information campaigns to combat this.
Tom P. Moorhouse   +3 more
semanticscholar   +1 more source

ExNOTic: Should We Be Keeping Exotic Pets?

open access: yesAnimals, 2017
There has been a recent trend towards keeping non-traditional companion animals, also known as exotic pets. These pets include parrots, reptiles, amphibians and rabbits, as well as small species of rodent such as degus and guinea pigs.
R. Grant, V. T. Montrose, A. Wills
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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