Journal of Fungi, 2020 In addition to the production of a host-selective toxin, the tangerine pathotype of Alternaria alternata must conquer toxic reactive oxygen species (ROS) in order to colonize host plants.
Pei-Ching Wu +5 more
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The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1. [PDF]
J Biol ChemThe heterohexameric ATPases associated with diverse cellular activities (AAA)-ATPase Pex1/Pex6 is essential for the formation and maintenance of peroxisomes.
Ali BA +9 more
europepmc +6 more sources
Transient Unexplained Severe Acute Hyperbilirubinaemia and Cholestasis in a Patient With Hereditary Spherocytosis. [PDF]
Case Reports HepatolHereditary spherocytosis is an inherited red cell membrane disorder resulting in haemolytic anaemia. Recognised clinical manifestations include anaemia, jaundice, splenomegaly and gallstones. Here we describe the case of a 40‐year‐old male with hereditary spherocytosis presenting with severe hyperbilirubinaemia.
Richardson J +3 more
europepmc +2 more sources
Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes. [PDF]
FEBS JIn this study, we analyzed how the dual‐localized AAA‐ATPase Msp1 handles Pex15. We show that newly synthesized Pex15 is primarily targeted to peroxisomes via the Pex19‐Pex3 pathway. Mitochondrial Msp1 extracts mistargeted Pex15, which is either sent to the ER via the GET pathway for degradation or redirected to peroxisomes via the Pex19‐Pex3 ...
Matsumoto S +4 more
europepmc +2 more sources
RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism [PDF]
Cell Communication and SignalingBackground Cervical cancer is the fourth most common cancer entity in women worldwide. Currently, malignant lesions are clinically managed by surgery, conventional chemotherapy, and/or radiotherapy.
Shaishavi Jansari +17 more
doaj +2 more sources
ArabidopsisABERRANT PEROXISOME MORPHOLOGY9 Is a Peroxin That Recruits the PEX1-PEX6 Complex to Peroxisomes [PDF]
The Plant Cell, 2011 Peroxisomes have pivotal roles in several metabolic processes, such as the detoxification of H2O2 and β-oxidation of fatty acids, and their functions are tightly regulated by multiple factors involved in peroxisome biogenesis, including protein transport.
Shoji Mano +3 more
core +3 more sources
Isolation of Penicillium chrysogenum PEX1 and PEX6 encoding AAA proteins involved in peroxisome biogenesis [PDF]
Applied Microbiology and Biotechnology, 2000 In Penicillium chrysogenum, key enzymes involved in the production of penicillin reside in peroxisomes. As a first step to understand the role of these organelles in penicillin biosynthesis, we set out to isolate the genes involved in peroxisome ...
Veenhuis, M +7 more
core +5 more sources
PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival [PDF]
Frontiers in Cellular and Infection MicrobiologyTrypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes.
Lavanya Mahadevan +5 more
doaj +2 more sources
Identification of Potential Feature Genes in CRSwNP Using Bioinformatics Analysis and Machine Learning Strategies [PDF]
Journal of Inflammation ResearchHuikang Wang,1– 3,* Xinjun Xu,1– 3,* Haoran Lu,1– 3 Yang Zheng,1– 3 Liting Shao,1– 3 Zhaoyang Lu,2– 4 Yu Zhang,2,3 Xicheng Song2,3 1Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, QingdaoUniversity, Yantai ...
Wang H +7 more
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Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families [PDF]
Annals of MedicineBackground Peroxisome biogenesis disorders (PBD) affect multiple organ systems. It is characterized by neurological dysfunction, hypotonia, ocular anomalies, craniofacial abnormalities, and absence of peroxisomes in fibroblasts.
Abdulfatah M. Alayoubi +5 more
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