Results 241 to 250 of about 27,275 (312)

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Perfluoroalkyl/Polyfluoroalkyl Substances, Hemostatic/Inflammatory Biomarkers, and Incident Hypertension: The Study of Women's Health Across the Nation. [PDF]

JACC Adv
Zhang Y, Zhang W, Karvonen-Gutierrez CA, Calafat AM, Herman WH, Mukherjee B, Park SK.   +6 more
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Case Report: First report of vonoprazan-associated severe Gly m 4-mediated PFAS anaphylaxis in the era of potent acid suppression. [PDF]

Front Allergy
Nojo M, Suzuki S, Uno T, Sato N, Kawafune S, Masuda R, Ebato T, Matsunaga T, Uchida Y, Sagara H, Tanaka A.   +10 more
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Hydrogeologic Drivers and Management Implications of PFAS, Nitrate, and Pharmaceuticals in Groundwater at a Karst Beneficial Reuse System. [PDF]

ACS ES T Water
Kosiarski K, Veith TL, Kibuye FA, Drohan PJ, Apul OG, Preisendanz HE.   +5 more
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Per- and polyfluoroalkyl substances (PFAS) exposure profiles for pregnant women living in urban, rural, and remote areas of Suriname, South America suggest higher serum concentrations in remote rainforest communities. [PDF]

J Expo Sci Environ Epidemiol
Honan JK, Abdoel Wahid F, Gokoel A, Lichtveld MY, Zijlmans W, Covert HH, Hindori-Mohangoo AD, Roosblad J, Codrington J, Huset CA, Barry KM, Peterson LA, Vevang KR, McCabe ME, Wickliffe JK.   +14 more
europepmc   +1 more source

Soil enzyme dynamics under PFAS contamination in arid and Mediterranean soils. [PDF]

NPJ Emerg Contam
Sanchez-Hernandez JC, Navarro Pacheco NI, Andrade Cares X, Semerád J, Cajthaml T, Megharaj M.   +5 more
europepmc   +1 more source