Results 191 to 200 of about 419,158 (294)

The adverse prognostic impact of reduced chemotherapy dose intensity appears attenuated in early breast cancer patients with treatment-relevant neutropenia: a retrospective cohort study. [PDF]

Arch Gynecol Obstet
Eissler K, Engler T, Dannehl D, Schönfisch B, Englisch J, Hartkopf AD, Brucker SY, Grischke EM, Volmer LL, Englisch A.   +9 more
europepmc   +1 more source

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

Epilepsia, EarlyView.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr, Advith S. Reddy, Neo Kok, Katherine N. McFarlane, Lavanya Biju, Jacqueline A. French   +5 more
wiley   +1 more source

Landscape of Genomic Mechanisms of Resistance to Selective RET Inhibitors in RET-Altered Solid Tumors: Analysis of the RETgistry Global Consortium. [PDF]

Clin Cancer Res
Waliany S, Cooper AJ, Liu SV, Gautschi O, Rotow JK, Smith KER, Weber UM, Lee DH, Loong HHF, Patel JD, Pennell NA, Nagasaka M, Patel SA, Tan DSW, Solomon BJ, Kim TM, Pall G, Riess JW, Sun L, Früh M, Uy NF, Gadgeel S, Feng J, Do A, Falcon C, Leighl NB, Baik CS, Lai GGY, Ou SI, Cheung KSY, Patil T, Mansfield AS, Weiler D, Yeap BY, Wirth LJ, Gainor JF, Drilon A, Lin JJ.   +37 more
europepmc   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Real-world effectiveness and safety of Sacituzumab Govitecan in metastatic triple-negative breast cancer: results from the multicenter retrospective observational SACISUR cohort in Southern Spain. [PDF]

Front Oncol
Falcón-González A, Llabrés-Valenti E, Henao-Carrasco F, Urbano-Cubero R, Godoy-Ortiz A, Nieto-Ramírez JC, Vargas-Prado AM, González-Haba A, Martín-Calero B, Morales-Estévez C, Valero-Arbizu M, Chavarría-Piudo N, González-Flores E, Casaut-Lora E, Díaz-Redondo T, Estalella-Mendoza S, Zarcos-Pedrinaci I, Morales-Pancorbo D, Acosta-Sánchez A, Vicente-Rubio E, Gil-Torralvo A, Cejuela-Solís M, De Toro-Salas R, Cano-Jiménez A, Pascual J, Sánchez-Guisado A, Cruz-Jurado J, De la Fuente-Domínguez I, Rodríguez-García JA, Torres-Zurita A, Salvador-Bofill J, Ruiz-Borrego M.   +31 more
europepmc   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

Real-world progression-free survival 2 (PFS2) and tumor response of CDK4/6 inhibitors plus an aromatase inhibitor in patients with HR+/HER2- metastatic breast cancer in US routine clinical practice. [PDF]

Breast
Rugo HS, Brufsky A, Layman RM, Liu X, Li B, McRoy L, Cohen AB, Estevez M, Lynce F, Cottu P, Thill M, Curigliano G.   +11 more
europepmc   +1 more source

Trajectories of quality of life, anxiety and depressive symptomatology, and health‐related work productivity after first seizure events

Epilepsia Open, EarlyView.
Abstract Objective First seizure events are common and may exert an immediate and profound impact on people's lives. Less understood are their long‐term consequences. This prospective, longitudinal study aimed to measure and compare psychosocial and health‐related work productivity trajectories following first seizure events of various etiologies ...
Emma Foster, Zhibin Chen, Alison Conquest, David N. Vaughan, Chris Tailby, Patrick W. Carney, Wendyl D’Souza, Hue Mun Au Yong, John‐Paul Nicolo, Jacob Pellinen, Danny Liew, Terence J. O’Brien, Patrick Kwan, Zanfina Ademi   +13 more
wiley   +1 more source

Signals of disproportionate reporting of events supposedly attributable to COVID-19 vaccines in children and adolescents: case-non-case study, Brazil, 2022. [PDF]

Epidemiol Serv Saude
Silva RMA, Nóbrega MEBD, Percio J, Martins AF, Almeida SLR, Porto VBG.   +5 more
europepmc   +1 more source

A Comparison of Realized Measures of Integrated Volatility: Price Duration‐ vs. Return‐Based Approaches

Journal of Forecasting, EarlyView.
ABSTRACT We study the accuracy of a variety of parametric price duration‐based realized variance estimators constructed via various financial duration models and compare their forecasting performance with the performance of various nonparametric return‐based realized variance estimators.
Björn Schulte‐Tillmann, Mawuli Segnon, Timo Wiedemann   +2 more
wiley   +1 more source