CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO-TA-Induced Cardiac Senescence via Mitophagy Defect and cGAS-STING Activation: In Vitro Amelioration by Cycloastragenol. [PDF]
Adv Sci (Weinh)The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Li NW +6 more
europepmc +2 more sources
Degradation of Perfluorooctanoic Acid (PFOA) on Aluminum Oxide Surfaces: New Mechanisms from Ab Initio Molecular Dynamics Simulations [PDF]
, 2023 Perfluorooctanoic acid (PFOA) is a part of a large group of anthropogenic, persistent, and bio-accumulative contaminants known as per- and polyfluoroalkyl substances (PFAS) that can be harmful to human health. In this work, we present the first ab initio
Bryan, Wong, Sohag, Biswas
core +2 more sources
Geocoding rural addresses in a community contaminated by PFOA: a comparison of methods. [PDF]
, 2010 BACKGROUND: Location is often an important component of exposure assessment, and positional errors in geocoding may result in exposure misclassification.
Vieira Verónica M +15 more
core +2 more sources
Ecotoxicology and Environmental Safety, 2021 Perfluorooctanoic acid (PFOA) is an environmental pollutant that has multiple toxic effects. Although some medicines and functional food ingredients are currently being used to alleviate the biological toxicity effects caused by PFOA, these candidates ...
Liuting Shi +7 more
doaj +1 more source
Synthesis, properties and applications of perfluorooctanoic acid (PFOA) [PDF]
, 2022 openQuesto elaborato di tesi si propone di raccogliere e commentare le informazioni che riguardano le principali vie sintetiche per la molecola PFOA, i dati relativi alla sua produzione e conseguenti emissioni nell’ambiente con gli effetti sulla salute ...
VIGNAGA, ROBIN
core
Immunometabolism-modulation and immunotoxicity evaluation of perfluorooctanoic acid in macrophage
Ecotoxicology and Environmental Safety, 2021 Perfluorooctanoic acid (PFOA) is one of the most commonly used perfluorinated chemicals in industry. Wide concerns of PFOA toxicity are increased in recent years. However, report on immunotoxicity of PFOA was quite limited.
Jinglin Tian +6 more
doaj +1 more source
Assessing the Spatial Distribution of Perfluorooctanoic Acid Exposure via Public Drinking Water Pipes Using Geographic Information Systems. [PDF]
, 2013 OBJECTIVES: Geographic Information Systems (GIS) is a powerful tool for assessing exposure in epidemiologic studies. We used GIS to determine the geographic extent of contamination by perfluorooctanoic acid, C8 (PFOA) that was released into the ...
Fletcher, Tony +2 more
core +1 more source
A Study on the Detection Characteristics of PFOA, PFOS, and PFHxS among Perfluorinated Compounds in the Geum River Basin [PDF]
대한환경공학회지The present study conducted a preliminary investigation of perfluorinated compounds (PFCs) within the Geum River Basin, focusing on potential contamination sources such as downstream areas, wastewater treatment plants, and major rivers in the basin.
Deul Re Min +5 more
doaj +1 more source
Fe3+ Promoted the Photocatalytic Defluorination of Perfluorooctanoic Acid (PFOA) over In2O3
, 2021 In this study, four kinds of In2O3 photocatalysts were prepared by a facile calcination process at different temperatures and used for the removal of perfluorooctanoic acid (PFOA) from contaminated water.
Zhang, Liwu +8 more
core +1 more source
Scandinavian Journal of Work, Environment & Health, 2010 OBJECTIVE: Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women.
Chunyuan Fei +3 more
doaj +1 more source