Results 181 to 190 of about 49,868 (226)

Targeted PGC-1α gene delivery by GV-assisted ultrasound cavitation for renal ischemia-reperfusion injury therapy. [PDF]

iScience
Kuai Y, Xu W, Wang X, Xu X, Huang P.
europepmc   +1 more source

Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is known to promote muscle wasting and cellular senescence, largely by impairing mitochondrial function.
Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo   +6 more
wiley   +1 more source

γ-Elemene Impairs Mitochondrial Biogenesis in Breast Cancer Cells by Upregulating GCN5-Mediated PGC-1α Acetylation. [PDF]

Biomol Ther (Seoul)
Tang L, Wang M, Liu J, Yu Q, Chen C, Jia L, Xia J.   +6 more
europepmc   +1 more source

The Nexus of Stemness, Telomere Stability, and Metabolic Reprogramming in Glioblastoma: Foundations of Tumor Persistence and Targets for Intervention

MedComm, Volume 7, Issue 4, April 2026.
Integrated schematic depicting the interplay between glioma stem‐like cells, telomere maintenance mechanisms, and metabolic reprogramming in shaping immune suppression and therapeutic resistance in glioblastoma . ABSTRACT Glioblastoma (GBM) is a highly aggressive, therapy‐resistant brain tumor with inevitable recurrence despite maximal multimodal ...
Ji‐Yong Sung, Kihwan Hwang
wiley   +1 more source

PGC-1α regulates lipid accumulation by coordinating fatty acid synthesis and oxidation in goose fatty liver. [PDF]

Poult Sci
Li J, Lv M, Liu L, Geng T, Gong D, Zhao M.   +5 more
europepmc   +1 more source

Nanoceria Nanozyme Attenuates CoCl2‐Induced Oxidative Stress and Mitochondrial Dysfunction in H9c2 Cardiomyoblasts

Nano Select, Volume 7, Issue 4, April 2026.
This study shows that nanoceria protect H9c2 cardiomyoblasts from CoCl2‐induced chemical stress. Nanoceria reduces reactive oxygen species, preserves mitochondrial function, and regulates genes involved in antioxidant defense, intrinsic apoptosis, and inflammation. These findings highlight nanoceria's potential as a redox‐active nanozyme for protecting
Rukhsana Gul, Arwa Bazighifan, Mushtaq A. Dar, Shahid Nawaz, Assim A. Alfadda   +4 more
wiley   +1 more source

Transcriptome Comparison Between the Cultured and In Vivo Chick Primordial Germ Cells by SMART‐Seq‐Based Single‐Cell RNA Sequencing

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
Cultivation of PGCs triggers a transition from MYC‐ to MYCN‐driven transcriptional regulation. ABSTRACT Primordial germ cells (PGCs), the precursors of the germline, have unique cellular characteristics to undergo long‐distance migration to the embryonic gonads and have the potential to differentiate into somatic cells. Among the animal models studying
Yoshiki Hayashi, Atsushi Doi, Hiroko Iikawa, Hirokazu Kimijima, Yutaka Suzuki, Akinori Kanai, Hideki Hirakawa, Daisuke Saito   +7 more
wiley   +1 more source

Predictive model of delayed union of tibial and fibular fractures based on PGC-1α, NOS, and Runx2. [PDF]

Eur J Med Res
Wang B, Shi Z, Li D, Yu J.
europepmc   +1 more source

Efficacy and safety of rimegepant for the acute treatment of migraine in Black or African American adults: A post hoc pooled subgroup analysis from three randomized, placebo‐controlled clinical trials

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 874-884, April 2026.
Abstract Objective This post hoc subgroup analysis was conducted using pooled data from three US‐based clinical trials to compare efficacy and safety of rimegepant 75 mg versus placebo in acute migraine in adults who are Black or African American.
Larry Charleston IV, Cynthia E. Armand, Teshamae S. Monteith, Hope L. O'Brien, Chandra C. Abbott, Glenn C. Pixton, Terence Fullerton   +6 more
wiley   +1 more source

Naa10p impairs PGC-1α/Pparγ2 interaction to inhibit mitochondrial protection in pancreatitis. [PDF]

J Cell Commun Signal
Du J, Jiang H, Zhang T, Zheng C, Ji Z.
europepmc   +1 more source