Results 201 to 210 of about 49,868 (226)

Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
John Z. Chan, Antonia N. Berdeklis, Ming Rong Liu, Fasih A. Rahman, Michelle V. Tomczewski, Mackenzie Q. Graham, Musa Musa, Alex D. Cocco, Ken D. Stark, Joe Quadrilatero, Robin E. Duncan   +10 more
wiley   +1 more source

High-intensity intermittent training promotes adipose tissue browning via the IL-27/p38 MAPK-PGC-1α signaling pathway in diet-induced obese rats. [PDF]

Front Physiol
Wang C, Hu Y, Chen J, Wu Y.
europepmc   +1 more source

Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin, Benedikt Gasser, Giraud Marie‐Noëlle   +2 more
wiley   +1 more source

<i>Phellinus linteus</i> polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation. [PDF]

Am J Cancer Res
Wei W, Huang J, Xie L, Xu Z, Lin C, Chen M.   +5 more
europepmc   +1 more source

SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification. [PDF]

Sci Rep
Wu C, Wu Z, Hu L, Tang L, Hu X, Fang C.
europepmc   +1 more source

AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy. [PDF]

CNS Neurosci Ther
Chen J, Liu B, Yao X, Yang X, Sun J, Yi J, Xue F, Zhang J, Shen Y, Chen B, Sun H.   +10 more
europepmc   +1 more source

Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis. [PDF]

Int J Biol Sci
Chen J, Wu D, Huang C, Yan Z, Wang J, Li S, Chen X, Zhu Y, Zhang Y.   +8 more
europepmc   +1 more source

Headache‐associated photophobia is more prevalent during winter: A cross‐sectional study from a pediatric headache registry

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 996-998, April 2026.
Carlyn Patterson Gentile, Geoffrey K. Aguirre, Andrew D. Hershey, Christina L. Szperka   +3 more
wiley   +1 more source

High-intensity interval training alleviates COPD-induced gastrocnemius muscle dysfunction via the BRD4/PGC-1α axis through restoring mitochondrial function and oxidative fiber composition. [PDF]

J Muscle Res Cell Motil
Zhu C, Peng W, Yang L, Zhang W.
europepmc   +1 more source

Cardioprotective Effects of Soluble Guanylate Cyclase and Its α1 Subunit on Myocardial Ischemia/Reperfusion Injury via the PGC-1α/UCP2 Pathway. [PDF]

J Cardiovasc Pharmacol
Li J, Li X, Chen Y, Fang L, Li Q, Wu H, Liu Y, Qi X, Wei L, Wei L.   +9 more
europepmc   +1 more source