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Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney

Prostaglandins & Other Lipid Mediators, 2018
Prostaglandin E2 (PGE2) is the most abundant prostanoid synthesized in the kidney and plays an important role in renal function. Physiologically, PGE2 regulates renal hemodynamics, water and sodium metabolism, blood pressure, and so on. As a well-known proinflammatory lipid mediator, PGE2 also substantially mediates renal injury under many ...
Xiaoyan Zhang   +4 more
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PGE2 vs PGF2α in human parturition

Placenta, 2021
Prostaglandin E2 (PGE2) and F2α (PGF2α) are the two most prominent prostanoids in parturition. They are involved in cervical ripening, membrane rupture, myometrial contraction and inflammation in gestational tissues. Because multiple receptor subtypes for PGE2 and PGF2α exist, coupled with diverse signaling pathways, the effects of PGE2 and PGF2α ...
Wangsheng Wang   +6 more
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Diminished PGE2 content, enhanced PGE2 release and defects in 3H-PGE2 transport in embryos from overtly diabetic rats

Reproduction, Fertility and Development, 2000
Diminished PGE2 levels in diabetic embryos are related to the development of malformations, and thus the aim of the present study was to determine whether PGE2 levels are modified in rat embryos cultured in diabetic serum during organogenesis, and if PGE2 content and release, and 3H-PGE2 uptake and release, are altered in incubated diabetic embryos ...
Verónica White   +5 more
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PGE2, PGF2α and catecholaminesinpheochromocytoma

Prostaglandins, Leukotrienes and Medicine, 1982
In order to relate urinary prostaglandin excretion in pheochromocytoma /Ph/ to the pattern of noradrenaline /NA/, adrenaline /A/ and dopamine /D/, 14 patients with this disease were investigated during normal sodium intake. 20 healthy volunteers served as controls /C/. Urinary PGs were determined by RIA; NA, A and D were measured fluorometrically.
B. Wocial   +3 more
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Antifertility effects of PGE2 and PGF2α

Contraception, 1974
Abstract The effectiveness of prostaglandins to modify egg transport, to stimulate uterine contractility and to induce luteolysis suggested their possible role as postcoital contraceptives. PGE 2 and PGF 2α were injected at 24 hours postcoitum (h p.c.) or at 4 days postcoitum (d p.c.) in rabbits. Effects on fertility were studied at autopsy 14 d p.c.
E.S.E. Hafez   +2 more
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Intravaginal PGE2 in early abortion

Prostaglandins, 1974
Abstract Intravaginal PGE2 was administered to 10 women in early (less than 50 days) pregnancy. Complete abortion was effected in 8, an incomplete abortion in one and one was a failure. Significant systemic side effects were noted in all subjects. Urinary hCG excretion rates prior to and on the 2nd and 14th day after PGE2 showed a decrease in all ...
William Bienart   +2 more
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PgE2-Gel und PgE2-Vaginaltabletten zur Geburtseinleitung - eine prospektive randomisierte Studie

Geburtshilfe und Frauenheilkunde, 1994
In a prospective randomised study, the effects of an intracervical gel containing 0.5 mg PgE2 and an intravaginal tablet containing 3 mg PgE2 were compared in their efficiency to induce delivery at term. When only gel was used, induction failed in 45% of the cases, especially with an initially immature cervix score.
C. Heiss   +3 more
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Receptor binding in various tissues of PGE2, PGF2α and sulprostone, a novel PGE2-derivative

Prostaglandins, 1979
Sulprostone is a tissue-specific PGE2-derivative with high abortifacient activity in various species including man. The dissociation constant KD of the receptor binding of this compound was compared with PGE2 and PGF2 alpha in various tissue preparations of different species.
S Wellershoff   +3 more
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The placenta, PGE2 and parturition

Early Human Development, 1992
It is proposed that prostaglandin E2 (PGE2), secreted by the fetal placenta of the sheep, acts as a circulating regulator of the physiological function of many fetal organs (tissue) in a way analogous to catecholamines in the adult. The specificity of PGE2 action in different tissues is determined by three different receptor subtypes which regulate ...
openaire   +3 more sources

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