Results 371 to 380 of about 158,535 (386)
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Science Translational Medicine, 2014
By chelating bioactive PGE2, a molecule with immunosuppressive properties, albumin helps preserve normal immune function.
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By chelating bioactive PGE2, a molecule with immunosuppressive properties, albumin helps preserve normal immune function.
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Circulating and urinary metabolites of PGE2 and PGF2a
Prostaglandins, 1984Abstract Fig. 1 summarizes the structures of primary PGE2 and PGF2a (upper line), their initially formed 15-ketodihydro-metabolites which appera early in blood after release (middle), and their β- and ω-oxidized metabolites, which appear later and remain longer in the circulation and also dominate the urinary profile (lower line).
Elisabeth Granström, Hans Kindahl
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Suppression of human lymphocyte migration by PGE2
Inflammation, 1981Prostaglandin (PG) E2 markedly inhibits casein- and C5a-stimulated lymphocyte migration in a concentration-dependent manner. Inhibition is observed with as low as 10(-9) M PGE2 and requires that PGE2 be present during cell locomotion. Studies with PGE1, PGF1 alpha, PGF2 alpha and PGA1 indicate that only PGE1 and PGE2 inhibit lymphocyte migration. These
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Nasal vasoconstrictor activity of a novel PGE2 analog
Prostaglandins, 1981A novel PGE2 analog (CL 116,069) was shown to be effective in dogs as a nasal decongestant. Threshold doses were approximately 0.1 microgram/kg with intravenous administration and between 0.08 and 4 microgram with topical administration. CL 116,069 was compared to 17-phenyltrinor PGE2 (CL 116,147), a compound recently studied in humans, and ...
Jay E. Birnbaum, Richard T. Jackson
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Inhibition of renal PGE2-9-ketoreductase by diuretics
Prostaglandins, 1976The metabolism of PGE2 by extracts of renal cortex is species dependent. In the rat PGE2-15-hydroxydehydrogenase initiates metabolism whereas in the rabbit PGE2-9-ketoreductase predominates. In man both mechanisms may operate. Each of the metabolic enzymes, which limits the vasodilator-diuretic actions of PGE2, was inhibited by ethacrynic acid ...
K.J. Stone, M. Hart
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PGE2 binding, synthesis, and distribution in hen oviduct
American Journal of Physiology-Endocrinology and Metabolism, 1985Prostaglandin E2 (PGE2) bound specifically to particulate fractions prepared from the vagina and uterus (shell gland) portions of the hen oviduct in a time and temperature dependent fashion. Scatchard analysis indicated a single class of high-affinity binding sites in the vagina (Kd congruent to 1 nM), whereas the myometrium exhibited two kinds of ...
F. Hertelendy +3 more
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Synthesis and PGE2 inhibitory activity of novel diarylheptanoids
Bioorganic & Medicinal Chemistry Letters, 2018Prostaglandin E2 (PGE2) is a lipid mediator of inflammation and its inhibition has become a popular drug target due to its harmful physiological roles. Diarylheptanoids are one class of compounds that have shown successful inhibition of PGE2. This paper reports the synthesis and PGE2 inhibitory activity of a series of analogues of a naturally occurring
Richard D. McLane +7 more
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Role of PGE2 in the modulation of the adrenergic response in man
Cardiovascular Research, 1983The influence of sympathetic stimulation (SS) (achieved by 2 min cold application) on the plasma concentration of PGE2, PGF2 alpha (radioimmunoassay), noradrenaline (NA) and adrenaline (A) (radioenzymatic assay) and on forearm vascular resistance (indirect measurement, FVR) was studied in 16 healthy volunteers before and after cyclooxygenase inhibition
G. G. Neri +5 more
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Metabolism of viprostol — A synthetic vasolidator PGE2 analog
Prostaglandins, 1986Metabolic studies were done with 14C-Viprostol (I) administered by various routes (I.V., oral and topical) to six animal species and to man. Total radioactivity and metabolic profiles were analyzed in plasma, tissues and excreta. The main metabolites were isolated and identified by capillary GC/MS.
G. Nicolau +5 more
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Salivary IL-1β and PGE2 as biomarkers of periodontal status, before and after periodontal treatment.
Journal of Clinical Periodontology, 2013AIM Interleukin-1β (IL-1β) and prostaglandin E2 (PGE2 ) are key inflammatory mediators involved in periodontitis. The purpose was to compare their salivary concentrations in relation to periodontal status and their changes after periodontal treatment, to
G. Sánchez +3 more
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