Results 31 to 40 of about 10,411 (116)

Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time‐Varying Relationship

International Journal of Cancer, EarlyView.
Experimental studies in animals suggest that oxidative stress (OxS) declines as cancer progresses. Whether this occurs in humans, however, remains unclear. The authors of the present study addressed this question by analyzing lipid, DNA, and RNA oxidation biomarkers in relation to colorectal cancer (CRC) risk in patients from Shanghai and the United ...
Gong Yang, Ginger L. Milne, Marina S. Nogueira, Yu‐Tang Gao, Qing Lan, Haoyang Yi, Xiao‐Ou Shu, Wei Zheng, Qingxia Chen   +8 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: modulation by inflammatory cytokines and role of the human aldose reductase AKR1B1. [PDF]

PLoS ONE, 2014
PGF2α may be involved in the regulation of adipose tissue function.1) To examine PGF2α release by primary preadipocytes, mature adipocytes and whole tissue explants from the subcutaneous and omental fat compartments; 2) To assess which PGF synthase is ...
Andréanne Michaud, Nicolas Lacroix-Pépin, Mélissa Pelletier, Alain Veilleux, Suzanne Noël, Céline Bouchard, Picard Marceau, Michel A Fortier, André Tchernof   +8 more
doaj   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

EFEKTIVITAS BERBAGAI WAKTU INJEKSI PGF2α SEBELUM PENAMPUNGAN SPERMA DOMBA LOKAL TERHADAP KUALITAS SPERMA DALAM PENGENCER TRIS YANG DISIMPAN PADA SUHU 5°C

Jurnal Ilmu Peternakan dan Veteriner Tropis, 2010
This experiment aimed to evaluate the effect of PGF2α and time of injection on the quality and viability of Local ram sperm in Tris dilution at 50C storage temperature. The sperm was collected from four Local rams with artificial vagina, once a week for one month. At the first week, sperm were collected without PGF2α injection; 10 minute after PGF2α
. Purwaningsih, . Sunardi
openaire   +1 more source

Comparison Between Intracornual Artificial Insemination and Uterine Body Deposition in Holstein-Friesian Heifers.

Revista de Producción Animal, 2015
Two insemination types were compared: intracornual and uterine body deposition in 40 Holstein-Friesian heifers in the province of Azuay, Cuenca Region, Cumbe and Victoria Portete Parishes.
Víctor Guillermo Serpa García , Rafael Antonio Ochoa Méndez , Diego Andrés Galarza Lucero   +2 more
doaj  

Direct and indirect effects of PGF2α administration in male wistar rats based on increased expression of α-SMA and androgen receptor

Open Veterinary Journal
Background: PGF2α hormone administration can improve semen quality through increased contractility of smooth muscle cells in testicular tissue and increased testosterone hormone.
Teuku Armansyah, Husnurrizal Husnurrizal, Sri Wahyuni, Hafizuddin Hafizuddin, Tongku Nizwan Siregar, Amalia Sutriana, Arman Sayuti, Adinda Tri Syahrani, Muhammad Bintang Pariansyah   +8 more
doaj   +1 more source

Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells

Animals, 2021
Intermediate filaments (IFs) maintain cell–cell adhesions and are involved in diverse cellular processes such as cytokinesis, cell migration and the maintenance of cell structure.
Sang-Hee Lee, Seunghyung Lee
doaj   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source