Results 11 to 20 of about 5,679 (109)

Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3

International Journal of Molecular Sciences, 2023
Arap3, a dual GTPase-activating protein (GAP) for the small GTPases Arf6 and RhoA, plays key roles in regulating a wide range of biological processes, including cancer cell invasion and metastasis.
Youjia Zhang, Liang Ge, Li Xu, Yongrui Liu, Jiarong Wang, Chongxu Liu, Hongxin Zhao, Lei Xing, Junfeng Wang, Bo Wu   +9 more
semanticscholar   +1 more source

Wild and Cultivated Homoeologous Barley Chromosomes Can Associate and Recombine in Wheat in the Absence of the Ph1 Locus

Agronomy, 2021
Bread wheat is an allohexaploid that behaves as a diploid during meiosis, the cell division process to produce the gametes occurring in organisms with sexual reproduction.
M. Calderón, P. Prieto
semanticscholar   +1 more source

Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient

Pediatric nephrology (Berlin, West), 2020
Background Primary hyperoxaluria type 1 (PH1) is a multisystemic metabolic disorder caused by an excessive production of oxalate by the liver. The majority of patients presenting in early infancy have end-stage renal disease (ESRD).
C. Kempf, A. Pfau, Johannes Holle, K. Müller-Schlüter, P. Bufler, F. Knauf, D. Müller   +6 more
semanticscholar   +1 more source

LB002ILLUMINATE-A, A PHASE 3 STUDY OF LUMASIRAN, AN INVESTIGATIONAL RNAI THERAPEUTIC, IN CHILDREN AND ADULTS WITH PRIMARY HYPEROXALURIA TYPE 1 (PH1)

Nephrology, Dialysis and Transplantation, 2020
PH1 is a rare genetic disorder characterized by hepatic oxalate overproduction, leading to recurrent kidney stones, nephrocalcinosis, progressive kidney failure, and multiorgan damage from systemic oxalosis.
Sander F. Garrelfs, Y. Frishberg, S. Hulton, M. Koren, W. O'Riordan, P. Cochat, G. Deschênes, H. Shasha-Lavsky, J. Saland, W. Hoff, D. Fuster, D. Magen, S. Moochhala, Gesa Schalk, E. Simkova, J. Groothoff, David J. Sas, K. Meliambro, Jiandong Lu, P. Garg, J. Gansner, T. McGregor, J. Lieske   +22 more
semanticscholar   +1 more source

Dual effect of the wheat Ph1 locus on chromosome synapsis and crossover

Chromosoma, 2017
Allopolyploids must possess a mechanism for facilitating synapsis and crossover (CO) between homologues, in preference to homoeologues (related chromosomes), to ensure successful meiosis.
Azahara C. Martín, M. Rey, P. Shaw, G. Moore   +3 more
semanticscholar   +2 more sources

Exploiting the ZIP4 homologue within the wheat Ph1 locus has identified two lines exhibiting homoeologous crossover in wheat-wild relative hybrids

Molecular breeding, 2017
Despite possessing related ancestral genomes, hexaploid wheat behaves as a diploid during meiosis. The wheat Ph1 locus promotes accurate synapsis and crossover of homologous chromosomes.
M. Rey, Azahara C. Martín, J. Higgins, D. Swarbreck, C. Uauy, P. Shaw, G. Moore   +6 more
semanticscholar   +1 more source

Magnesium Increases Homoeologous Crossover Frequency During Meiosis in ZIP4 (Ph1 Gene) Mutant Wheat-Wild Relative Hybrids

bioRxiv, 2018
Wild relatives provide an important source of useful traits in wheat breeding. Wheat and wild relative hybrids have been widely used in breeding programs to introduce such traits into wheat.
M. Rey, Azahara C. Martín, M. Smedley, S. Hayta, W. Harwood, P. Shaw, G. Moore   +6 more
semanticscholar   +1 more source

Introgression of the Aegilops speltoides Su1-Ph1 Suppressor into Wheat

Frontiers in Plant Science, 2017
Meiotic pairing between homoeologous chromosomes in polyploid wheat is inhibited by the Ph1 locus on the long arm of chromosome 5 in the B genome.
Hao Li, K. Deal, M. Luo, W. Ji, A. Distelfeld, J. Dvorak   +5 more
semanticscholar   +1 more source

Nedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8)

Pediatric nephrology (Berlin, West)
Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and renal failure, with potentially life-threatening ...
David J. Sas, S. Bakkaloğlu, V. Belostotsky, W. Hayes, Gema Ariceta, Jing Zhou, Verity Rawson   +6 more
semanticscholar   +1 more source

Bulgaristan Türklerinin Dilsel Kimliği: Tarihsel Politikalar ve Güncel Zorluklar

Comparative Turkish Dialects and Literatures
Bu makale, Bulgaristan’daki Türk azınlığın dilsel kimliğini koruma mücadelesini tarihsel ve güncel gelişmeler çerçevesinde ele almaktadır. Bulgaristan, etnik ve kültürel çeşitliliğe sahip bir ülke olup, Türkler en büyük azınlık grubunu oluşturmaktadır ...
Harun Bekir
doaj   +1 more source