Results 131 to 140 of about 15,498,960 (208)

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

open access: yesThe FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal   +4 more
wiley   +1 more source

Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model. [PDF]

open access: yesFASEB J
Tadayonfar R   +7 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

Is Gillnet Prey Subsidizing Ontogenetic Diet Shifts and Early Weaning in Common Coastal Bottlenose Dolphins From the Southwestern Gulf of Mexico?

open access: yesFisheries Management and Ecology, EarlyView.
ABSTRACT Artisanal gillnet fisheries can concentrate prey and provide incidental food subsidies to marine predators, but their effects on early‐life foraging behavior and demography remain poorly resolved. The Alvarado bottlenose dolphin population that lives off the coast of Veracruz, Mexico, is well known for having chronic, frequent, and recurring ...
Eduardo Morteo   +5 more
wiley   +1 more source

Studies Analyzing South American Public Policy Documents on Physical Activity: A Scoping Review. [PDF]

open access: yesEpidemiologia (Basel)
Pinheiro IKADS   +5 more
europepmc   +1 more source

Heuristic approaches for a new variant of the team orienteering problem

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract In this paper, we tackle the team orienteering problem (TOP) with service times, mandatory nodes and incompatibilities arising from two real‐world healthcare applications. We propose two heuristic algorithms: a variable neighbourhood descent algorithm and a matheuristic based on a cut separation approach.
Alberto Guastalla   +2 more
wiley   +1 more source

Heritability of Productive, Reproductive and Carcass Traits in Pure‐Bred and Cross‐Bred Pigs: A Systematic Review and Meta‐Analysis

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Heritability (h2) is a key parameter in animal breeding, but its magnitude and consistency across pure‐bred (PB) and cross‐bred (CB) pig populations remain poorly understood. This study aimed to compare heritability estimates between PB and CB populations for economically relevant traits through a systematic review and meta‐analysis.
Wilber Hernández‐Montiel   +6 more
wiley   +1 more source

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