RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model. [PDF]
Tadayonfar R +7 more
europepmc +1 more source
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa +1 more
wiley +1 more source
Dried Distillers' Grains with Solubles in Ruminant Diets: Effects on Enteric Methane Emissions and Production Responses-A Systematic Review. [PDF]
Mwanda L +4 more
europepmc +1 more source
ABSTRACT Artisanal gillnet fisheries can concentrate prey and provide incidental food subsidies to marine predators, but their effects on early‐life foraging behavior and demography remain poorly resolved. The Alvarado bottlenose dolphin population that lives off the coast of Veracruz, Mexico, is well known for having chronic, frequent, and recurring ...
Eduardo Morteo +5 more
wiley +1 more source
Studies Analyzing South American Public Policy Documents on Physical Activity: A Scoping Review. [PDF]
Pinheiro IKADS +5 more
europepmc +1 more source
Heuristic approaches for a new variant of the team orienteering problem
Abstract In this paper, we tackle the team orienteering problem (TOP) with service times, mandatory nodes and incompatibilities arising from two real‐world healthcare applications. We propose two heuristic algorithms: a variable neighbourhood descent algorithm and a matheuristic based on a cut separation approach.
Alberto Guastalla +2 more
wiley +1 more source
From Marshes to Mines: Germination and Establishment of <i>Crinum bulbispermum</i> on Gold Mine Tailings. [PDF]
Clarke VC +3 more
europepmc +1 more source
ABSTRACT Heritability (h2) is a key parameter in animal breeding, but its magnitude and consistency across pure‐bred (PB) and cross‐bred (CB) pig populations remain poorly understood. This study aimed to compare heritability estimates between PB and CB populations for economically relevant traits through a systematic review and meta‐analysis.
Wilber Hernández‐Montiel +6 more
wiley +1 more source
Effectiveness of buffered local anesthetic solutions in pediatric nerve blocks and infiltration anesthesia: a systematic review and meta-analysis. [PDF]
Bhatnagar A, Gupta D.
europepmc +1 more source

