Results 71 to 80 of about 5,490 (256)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Revista Árvore, 2012 Com relação aos atributos do solo, a produtividade de madeira do pinus varia substancialmente em função do pH, do teor de matéria orgânica e da resistência à penetração.
Carlos Eduardo Madureira Barbosa +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Correlação espacial dos atributos químicos do solo com o desenvolvimento da teca em Mato Grosso
Pesquisa Florestal Brasileira, 2012 O objetivo do trabalho foi investigar as correlações espaciais dos atributos químicos do solo com o desenvolvimento da teca (Tectona grandis) no município de Nossa Senhora do Livramento, MT. Foram alocadas 46 parcelas permanentes de 15 m x 30 m e obtidos
Allan Libanio Pelissari +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Efeito de sistemas de manejo em atributos químicos do solo
Pesquisa Agropecuária Gaúcha, 2007 Após nove anos de condução de um experimento em Latossolo Vermelho Distrófico típico, em Passo Fundo, RS, avaliaram-se os atributos químicos deste solo em quatro sistemas de manejo de solo: 1) plantio direto (PD), 2) cultivo mínimo (CM), 3) preparo ...
Gilberto Omar Tomm +3 more
doaj
Liming on picloram leaching in dystrophic Red Yellow Latosol
Revista Brasileira de Engenharia Agrícola e AmbientalThe practice of liming may influence the leaching of herbicides in soils, especially those with weak acid character, such as picloram. The study on leaching, preserving soil structure, is an important factor when one intends to understand the dynamics of
Mauricio Franceschi +5 more
doaj +1 more source
Revista Brasileira de Ciência do Solo, 2002 A magnitude das reações do N no solo varia com as condições climáticas, características do solo, tipo de preparo, forma de aplicação dos fertilizantes nitrogenados e manejo da cobertura vegetal morta.
P. R. Ernani, L. Sangoi, C. Rampazzo
doaj +1 more source