Results 301 to 310 of about 165,430 (355)

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, Volume 24, Issue 9, September 2025.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Functional and genomic analysis of Enterococcus phage A155: a potential agent for reducing VRE gut colonization. [PDF]

Virol J
Zeng H, Wang Y, Tian Y, Yao X, Li Y, Xu L, Yang X, Zhang X, Ma J.   +8 more
europepmc   +1 more source

Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies

Alimentary Pharmacology &Therapeutics, Volume 62, Issue 6, Page 568-584, September 2025.
26 studies were identified, reporting on 22 populations. Size ranged from 14 to 971 individuals (mean 170). Some reproducible data were identified; F. nucleatum and P. micra were significantly enriched in colorectal neoplasia compared to controls in 10 and 9 studies respectively. However, evidence quality was poor, limiting the comparability of studies.
Sarah Manning, Eleanor Hackney, Yashvee Dunneram, Mark A. Hull, Suparna Mitra, Christopher J. Stewart, Panayiotis Louca, Nick Meader, Linda Sharp, Colin Rees   +9 more
wiley   +1 more source

Phage quest: a beginner's guide to explore viral diversity in the prokaryotic world. [PDF]

Brief Bioinform
Wendling CC, Vasse M, Wielgoss S.
europepmc   +1 more source

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

The FEBS Journal, Volume 292, Issue 17, Page 4555-4579, September 2025.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon, Noëlla Germain‐Amiot, Charlotte Oriol, Astrid Rouillon, Yoann Augagneur, Stéphane Dréano, Irène Nicolas, Alexandre Chenal, Arnaud Bondon, Soizic Chevance, Marie‐Laure Pinel‐Marie   +10 more
wiley   +1 more source

Hepatopathy in a 4‐Month‐Old Holstein Calf After Transfusion With Plasma Containing Bovine Bosavirus

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT We report on the identification of bovine bosavirus associated with a post‐transfusion hepatopathy in a 4‐month‐old Holstein bull calf that was referred for enteritis and fever of unknown origin. Next‐generation sequencing (NGS) of post‐transfusion blood and liver tissue from the calf, alongside NGS of plasma from the donor, identified a ...
Simon F. Peek, Chelsea L. Holschbach, Alexandra J. Burton, Zuzanna W. Sikorska, LaTasha K. Crawford, Christopher D. Dunn, Tony L. Goldberg   +6 more
wiley   +1 more source

Isolation and characterization of a novel bacteriophage PUTH1 active against Pseudomonas aeruginosa. [PDF]

Virol J
Tan Q, Ye J, Zhu T, Tian Y.
europepmc   +1 more source

A Phylogenetic Host‐Range Index Reveals Ecological Constraints in Phage Specialisation and Virulence

Molecular Ecology, Volume 34, Issue 18, September 2025.
ABSTRACT Phages are typically known for having a limited host range, targeting particular strains within a bacterial species, but accurately measuring their specificity remains challenging. Factors like the genetic diversity or population dynamics of host bacteria are often disregarded despite their potential influence on phage specialisation and ...
Clara Torres‐Barceló, Claudine Boyer, Julian R. Garneau, Stéphane Poussier, Isabelle Robène, Benoît Moury   +5 more
wiley   +1 more source

Protocol for end-design-free rebooting of terminally redundant Pseudomonas phages in clinical isolates of Pseudomonas aeruginosa. [PDF]

STAR Protoc
Yokoyama D, Kimura N, Yamamoto H, Sakata Y, Fujiki J, Iwano H.   +5 more
europepmc   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, Volume 124, Issue 3, Page 189-203, September 2025.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source