Reversal of Virus-Induced Alveolar Macrophage Bactericidal Dysfunction by Cyclooxygenase Inhibition In Vitro [PDF]
Virus infection of alveolar macrophages (AM) both in vivo and in vitro has been associated with a decreased ability of these cells to kill bacteria, together with enhanced production of metabolites of arachidonic acid. These metabolites, especially PGE2,
J R Evermann +5 more
core +1 more source
Heterogeneity of inflammation and host metabolism in a typhoid fever model [PDF]
Systemic infections can lead to severe inflammation and altered host metabolism. These host responses are being extensively studied, but their spatial relationships in infected tissues remain largely unknown. The goal of this thesis was to investigate
Schemmer, Anne Kathrin
core +1 more source
Hyperoxia damages phagocytic defenses of neonatal rabbit lung [PDF]
The effect of hyperoxia on phagocytic defenses of neonatal rabbit lung was ascertained by exposure to a fractional inspired O2 concentration of 0.95 + or 0.21 for 48, 96, or 168 h.
M. P. Sherman, R. Condiotti
core +1 more source
Association Of Glucose-6-phosphate Dehydrogenase Deficiency And X-linkled Chronic Granulomatous Disease In A Child With Anemia And Recurrent Infections [PDF]
Patients with severe leukocyte G6PD deficiency may present with impairment of NADPH oxidase activity and a history of recurrent infections, mimicking the phenotype of chronic granulomatous disease.
Costa-Carvalho B.T. +6 more
core +1 more source
Phagocytic and metabolic activity of blood neurofils in rats with periodontitis on the background of hyper- and hypothyroidism [PDF]
Метою нашого дослідження було дослідити фагоцитарну та метаболічну активність нейтрофілів крові у щурів з пародонтитом без супутньої патології і на фоні гіпер- та гіпотиреозу.
Shcherba, V. V. +3 more
core +1 more source
Altered phagocyte function precedes death in polymicrobial sepsis [PDF]
Sepsis is an immunological condition defined by a pathogen inducing the Systemic Inflammatory Response Syndrome (SIRS), which itself is a clinical diagnosis involving temperature, heart rate, respiration, and white blood cell (WBC) count.
Chiswick, Evan L.
core
The roles of secreted protein acidic and rich in cystiene (Sparc) in intestinal inflammation, healing and fibrosis [PDF]
Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular protein expressed during tissue repair and regulates cell proliferation and migration.
Ng, Yoke Leng
core +1 more source
Cell-free expression and molecular modeling of the γ-secretase complex and G-protein-coupled receptors [PDF]
Alzheimer’s disease (AD), which was first reported more than a century ago by Alhzeimer, is one of the commonest forms of dementia which affects >30 million people globally (>8 million in Europe).
Ghoshdastider, Umesh
core
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje +3 more
wiley +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source

