Results 171 to 180 of about 367,624 (344)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Internal Density Calibration in the Proximal Humerus to Estimate Bone Stiffness for Stemless Shoulder Arthroplasty. [PDF]

J Orthop Res
Stiles CKA, Matheson BE, Athwal GS, Callaghan JP, Dickerson CR, Boyd SK, Knowles NK.   +6 more
europepmc   +1 more source

Phantom Evolution [PDF]

Annals of the ICRP, 2020
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Quantifying stent-induced dose perturbations in intravascular brachytherapy using 3D- printed phantoms and film dosimetry. [PDF]

J Appl Clin Med Phys
Jung JS, Huang L, Coupera N, Cao Y, Chang J.   +4 more
europepmc   +1 more source

High‐precision localization of radiation isocenter using Winston‐Lutz test: Impact of collimator angle, phantom position, and field size [PDF]

Weiliang Du
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Phantom epistasis through the lens of genealogies. [PDF]

Genetics
Ignatieva A, Ferreira LAF.
europepmc   +1 more source

Deadtime Measurements with a Multihole Phantom : Concise Communication

, 1981
SL. Heller
openalex   +2 more sources

Comparison of two ultrashort echo time sequences for the quantification of T₁ within phantom and human Achilles tendon at 3 T [PDF]

, 2012
P.J. Wright, Vladimı́r Jellúš, Dennis McGonagle, Matthew D. Robson, John Ridgeway, Richard Hodgson   +5 more
openalex   +1 more source