Results 81 to 90 of about 262,063 (357)
Physical Review D, 2004 12 pages, revtex, 3 figures, 1 table, references ...
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Editorial: Inorganic Chemistry Editor’s Pick 2021
Frontiers in Chemistry, 2021 Luís D. Carlos
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The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
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DiagnosticsBackground: To use the apparent diffusion coefficient (ADC) as reliable biomarkers, validation of MRI equipment performance and clinical acquisition protocols should be performed prior to application in patients.
Se Jin Choi +7 more
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Review of tissue-mimicking materials for anthropomorphic modeling of arterial vessels [PDF]
Digital DiagnosticsBACKGROUND: In computed tomographic angiography, anthropomorphic specimens made of tissue-mimicking materials are used to improve the diagnosis of pathological changes in arteries.
Dariya I. Abyzova, Maria R. Kodenko
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, 2008 One of the few advantages that India has over England is a great Knowability.
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Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
BioengineeringMultiparametric ultrasound (mpUS) enhances prostate cancer (PCa) diagnosis by using multiple imaging modalities. Tissue-mimicking materials (TMM) phantoms, favoured over animal models for ethical and consistency reasons, were created using polyvinyl ...
Adel Jawli, Ghulam Nabi, Zhihong Huang
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