Results 101 to 110 of about 714,652 (372)

Induced sensorimotor brain plasticity controls pain in phantom limb patients

open access: yesNature Communications, 2016
Pain in a phantom limb after limb deafferentation may be due to maladaptive sensorimotor representation. Here the authors find that sensorimotor plasticity induced by BMI training with the phantom hand, contrary to expectation, increased pain while ...
Takufumi Yanagisawa   +10 more
doaj   +1 more source

A review of current theories and treatments for phantom limb pain

open access: yesJournal of Clinical Investigation, 2018
Following amputation, most amputees still report feeling the missing limb and often describe these feelings as excruciatingly painful. Phantom limb sensations (PLS) are useful while controlling a prosthesis; however, phantom limb pain (PLP) is a ...
Kassondra L. Collins   +9 more
semanticscholar   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi   +4 more
wiley   +1 more source

Stimulation of the Semicircular Canals or the Utricles by Clinical Tests Can Modify the Intensity of Phantom Limb Pain

open access: yesFrontiers in Neurology, 2019
Background: After amputation, phantom limb pain may be produced by the multisensory processes underling the experience of an intact body. Clinical evidence has shown that cold caloric vestibular stimulation may modify the perception of phantom limb pain.
Catalina Aranda-Moreno   +5 more
doaj   +1 more source

Design and Validation of a MR-compatible Pneumatic Manipulandum [PDF]

open access: yes, 2007
The combination of functional MR imaging and novel robotic tools may provide unique opportunities to probe the neural systems underlying motor control and learning.
Scheidt, Robert A.   +2 more
core   +2 more sources

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó   +17 more
wiley   +1 more source

Recent advances in understanding and managing phantom limb pain

open access: yesF1000Research, 2019
Post-amputation phantom limb pain (PLP) is highly prevalent and very difficult to treat. The high-prevalence, high-pain intensity levels, and decreased quality of life associated with PLP compel us to explore novel avenues to prevent, manage, and reverse
A. Aternali, J. Katz
semanticscholar   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang   +7 more
wiley   +1 more source

Clinical feasibility and preliminary outcomes of a novel mixed reality system to manage phantom pain: a pilot study

open access: yesPilot and Feasibility Studies, 2022
Background To assess the clinical feasibility of a virtual mirror therapy system in a pilot sample of patients with phantom pain. Methods Our Mixed reality system for Managing Phantom Pain (Mr.
Thiru M Annaswamy   +5 more
doaj   +1 more source

Managing pain by visually distorting the size of painful body parts: is there any therapeutic value? [PDF]

open access: yes, 2016
Painful conditions such as complex regional pain syndrome, phantom limb pain and low back pain may change the sense of body image, so that body parts are perceived as large, swollen, heavy or stuck in one position [1]. In 1995, Ramachandran et al.
Johnson, MI, Wittkopf, PG
core   +1 more source

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